Evidence map›Paper›PMID 32910305›Full record

ArticleNeurotoxicity research2020

Peripheral Pain Modulation of Chrysaora pacifica Jellyfish Venom Requires Both Ca

Hye-Ji Kim, Jin-Woo Noh, Khulan Amarsanaa, Sang-Chan Jeon, Yoon-Sil Yang, Na-Hye Hwang, Eun-A Ko, Young-Joon Kang, Sung-Cherl Jung

Abstract read
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In one paragraph

Article in Neurotoxicity research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Voltage-dependent CaPflugers Archiv : European journal of physiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hye-Ji KimDepartment of Physiology, School of Medicine, Jeju National University, Jeju, 63243, Republic of Korea.
Jin-Woo NohDepartment of Physiology, School of Medicine, Jeju National University, Jeju, 63243, Republic of Korea.
Khulan AmarsanaaDepartment of Physiology, School of Medicine, Jeju National University, Jeju, 63243, Republic of Korea.
Sang-Chan JeonDepartment of Physiology, School of Medicine, Jeju National University, Jeju, 63243, Republic of Korea.
Yoon-Sil YangDepartment of Structure and Function of Neural Network, Korea Brain Research Institute, Daegu, 41068, Republic of Korea.
Na-Hye HwangDepartment of Physiology, School of Medicine, Jeju National University, Jeju, 63243, Republic of Korea.
Eun-A KoDepartment of Physiology, School of Medicine, Jeju National University, Jeju, 63243, Republic of Korea.
Young-Joon KangDepartment of Emergency Medicine, School of Medicine, Jeju National University, Jeju, 63243, Republic of Korea.
Sung-Cherl JungDepartment of Physiology, School of Medicine, Jeju National University, Jeju, 63243, Republic of Korea. jungsc@jejunu.ac.kr.ORCID https://orcid.org/0000-0001-5478-2413
Jeju National University · KRKorea Brain Research Institute · KR

Funding

National Research Foundation of Korea NRF-2016R1D1A1B0101086
6 · The paper itself

Abstract

The venom of jellyfish triggers severe dermal pain along with inflammation and tissue necrosis, and occasionally, induces internal organ dysfunction. However, the basic mechanisms underlying its cytotoxic effects are still unknown. Here, we report one of the mechanisms involved in peripheral pain modulation associated with inflammatory and neurotoxic oxidative signaling in rats using the venom of jellyfish, Chrysaora pacifica (CpV). This jellyfish is identified by brown tentacles carrying nematocysts filled with cytotoxic venom that induces severe pain, pruritus, tentacle marks, and blisters. The subcutaneous injection of CpV into rat forepaws in behavioral tests triggered nociceptive response with a decreased threshold for mechanical pain perception. These responses lasted up to 48 h and were completely blocked by verapamil and TTA-P2, T-type Ca

Indexed as

AnimalsCalciumCnidarian VenomsDose-Response Relationship, DrugInjections, SubcutaneousMaleNeuralgiaPain MeasurementRatsRats, Sprague-DawleyTRPA1 Cation ChannelCalciumCnidarian Venomssea nettle toxinTRPA1 Cation ChannelTrpa1 protein, ratChrysaora pacificaInflammatory painJellyfish venomROSTRPA1T-type Ca2+ channel

Identifiers

PMID32910305
OpenAlexW3084507771

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.