ArticleIntensive care medicine experimental2020
Repeated measures of Heparin-binding protein (HBP) and procalcitonin during septic shock: biomarker kinetics and association with cardiovascular organ dysfunction.
Article in Intensive care medicine experimental, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Time over minimum inhibitory concentration and variations in beta-lactam concentrations during prolonged and intermittent infusions in patients with septic shock: A post hoc observational study.The Journal of international medical research · 2026Observational
- Pediatric community-acquired pneumonia: predictive value of heparin-binding protein for severity assessment.Pediatric research · 2026Observational
- The value of NLRP, PCT, and HBP for sepsis-associated acute kidney injury and the effect of anti-inflammatory drugs.Medicine · 2026Article
- Diagnostic and prognostic value of serum HBP combined with PCT, CRP, and SAA in early-stage pneumonia.Virology journal · 2026Article
- Associations of Inflammatory Biomarkers with Disease Severity in Elderly Patients with Sepsis-Associated ARDS: A Cross-Sectional Study.Clinical interventions in aging · 2026Article
- Circulating biomarkers of vasoplegia: a systematic review.Annals of intensive care · 2025Review
- Heparin Binding Protein in Sepsis-A Comprehensive Overview of Pathophysiology, Clinical Usage and Utility as Biomarker.Biomedicines · 2025Review
- Heparin-binding Protein as a Diagnostic and Prognostic Marker of Infections: A Systematic Review and Meta-analysis.Mediterranean journal of hematology and infectious diseases · 2025Review
- Screening and Application of DNA Aptamers for Heparin-Binding Protein.Molecules (Basel, Switzerland) · 2024Article
- Heparin-binding protein as a predictor of mortality in patients with diabetes mellitus and community-acquired pneumonia in intensive care unit : a propensity score matched study.World journal of emergency medicine · 2024Article
- Utility of heparin-binding protein following cardiothoracic surgery using cardiopulmonary bypass.Scientific reports · 2023Observational
- Serum C reactive protein and procalcitonin are valuable predictors of coronary heart disease and poor prognosis in the elderly.American journal of translational research · 2023Article
- The Predictive Value of Heparin-Binding Protein and D-Dimer in Patients with Sepsis.International journal of general medicine · 2023Article
- Hepcidin discriminates sepsis from other critical illness at admission to intensive care.Scientific reports · 2022Article
- Dynamic changes in heparin-binding protein as a prognostic biomarker for 30-day mortality in sepsis patients in the intensive care unit.Scientific reports · 2022Observational
- Heparin-binding protein-enhanced quick SOFA score improves mortality prediction in sepsis patients.Frontiers in medicine · 2022Article
- The Dynamics of Circulating Heparin-Binding Protein: Implications for Its Use as a Biomarker.Journal of innate immunity · 2022Article
- Diagnostic value of heparin-binding protein in the cerebrospinal fluid for purulent meningitis in children.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Article
- Clinical utility of procalcitonin in bacterial infections in patients undergoing hematopoietic stem cell transplantation.American journal of blood research · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHeparin-binding protein (HBP) is a neutrophil-derived pro-inflammatory protein, an inducer of endothelial dysfunction and vascular permeability and a promising prognostic biomarker in sepsis. This exploratory study aims to describe the kinetics of plasma HBP during septic shock and investigate an association between repeated measures of HBP concentration and cardiovascular organ dysfunction severity.
methodsWe included patients at or above 18 years with suspected septic shock on admission to the intensive care unit (ICU) during 2014 and 2016 to 2018. Plasma samples were collected from ICU admission and every 4 h for 72 h or until death or ICU discharge and batch analysed for HBP. Mean arterial blood pressure (MAP) and noradrenaline dose (NA dose) were recorded at each sampling time point, and systemic vascular resistance index (SVRI) was recorded when available from non-invasive monitoring. The association between HBP, NA dose, MAP and SVRI was assessed respectively using mixed-effects linear regression models. Procalcitonin (PCT) was used as a comparator.
resultsA total of 24 patients were included. The kinetics of plasma HBP was highly variable over time, with occasional >2-fold increases and decreases in between 4-h measurements. Every 100 ng/mL increase in HBP corresponded to a 30% increase in NA dose in a crude model (95% CI 3 to 60%, p = 0.03, n
conclusionsPlasma HBP displayed a highly variable kinetic pattern during septic shock and was significantly associated to cardiovascular organ dysfunction severity over time.
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