ArticleEuropean journal of applied physiology2020
Spleen contraction elevates hemoglobin concentration at high altitude during rest and exercise.
Article in European journal of applied physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Splenic contraction associated with sudden, transient hypotension and sympathoexcitation in humans.Experimental physiology · 2026Article
- Spleen contraction verified as a supportive autopsy sign of fatal hypothermia.International journal of legal medicine · 2026Article
- Acute and chronic application of novel incremental breath-hold technique increases endurance exercise performance in healthy men and male military personnel.Physiological reports · 2026Article
- Myeloperoxidase regulates hypoxia-induced inflammation and oxidative stress in liver-spleen axis.Journal of inflammation (London, England) · 2026Article
- Exercise in Hypoxic Environments: An Overview of Systematic Reviews on Performance, Physiological Adaptation, and Clinical Implications.Sports (Basel, Switzerland) · 2026Review
- [Sex-specific hemoglobin thresholds for oxygen saturation: A non-linear regression analysis based on Tibetan inpatients].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Article
- Impact of acute and chronic hypoxia on the heme oxygenase/carbon monoxide pathway in naked mole-rats (Heterocephalus glaber).The Journal of experimental biology · 2025Article
- Cocaine abuse and its impact on the thymus and spleen.Histology and histopathology · 2025Review
- Splenic modulation of the early inflammatory response to regional and global ischemia/reperfusion injury in swine.American journal of physiology. Heart and circulatory physiology · 2025Article
- Accelerated Red Blood Cell Turnover Following Extreme Mountain Ultramarathon?Medicine and science in sports and exercise · 2025Article
- Red blood cell passage through deformable interendothelial slits in the spleen: Insights into splenic filtration and hemodynamics.Computers in biology and medicine · 2024Article
- Skill building in freediving as an example of embodied culture.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Acute Effects of Breath-Hold Conditions on Aerobic Fitness in Elite Rugby Players.Life (Basel, Switzerland) · 2024Article
- Article
- Differential splenic responses to hyperoxic breathing at high altitude in Sherpa and lowlanders.Experimental physiology · 2024Article
- Sex-based variations in breath-holding: oxygen storage and diving response among non-divers.Frontiers in physiology · 2024Article
- Larger splenic emptying correlate with slower EPOC kinetics in healthy men and women during supine cycling.European journal of applied physiology · 2023Article
- Multidetector CT Imaging Biomarkers as Predictors of Prognosis in Shock: Updates and Future Directions.Diagnostics (Basel, Switzerland) · 2023Review
- Splenic contraction and cardiovascular responses are augmented during apnea compared to rebreathing in humans.Frontiers in physiology · 2023Article
- Integrative Analysis of Proteomics and Metabolism Reveals the Potential Roles of Arachidonic Acid Metabolism in Hypoxia Response in Mouse Spleen.Molecules (Basel, Switzerland) · 2022Article
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5 authors.
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Abstract
purposeHypoxia and exercise are known to separately trigger spleen contraction, leading to release of stored erythrocytes. We studied spleen volume and hemoglobin concentration (Hb) during rest and exercise at three altitudes.
methodsEleven healthy lowlanders did a 5-min modified Harvard step test at 1370, 3700 and 4200 m altitude. Spleen volume was measured via ultrasonic imaging and capillary Hb with Hemocue during rest and after the step test, and arterial oxygen saturation (SaO
resultsResting spleen volume was reduced with increasing altitude and further reduced with exercise at all altitudes. Mean (SE) baseline spleen volume at 1370 m was 252 (20) mL and after exercise, it was 199 (15) mL (P < 0.01). At 3700 m, baseline spleen volume was 231 (22) mL and after exercise 166 (12) mL (P < 0.05). At 4200 m baseline volume was 210 (23) mL and after exercise 172 (20) mL (P < 0.05). After 10 min, spleen volume increased to baseline at all altitudes (NS). Baseline Hb increased with altitude from 138.9 (6.1) g/L at 1370 m, to 141.2 (4.1) at 3700 m and 152.4 (4.0) at 4200 m (P < 0.01). At all altitudes Hb increased from baseline during exercise to 146.8 (5.7) g/L at 1370 m, 150.4 (3.8) g/L at 3700 m and 157.3 (3.8) g/L at 4200 m (all P < 0.05 from baseline). Hb had returned to baseline after 10 min rest at all altitudes (NS). The spleen-derived Hb elevation during exercise was smaller at 4200 m compared to 3700 m (P < 0.05). Cardiorespiratory variables were also affected by altitude during both rest and exercise.
conclusionsThe spleen contracts and mobilizes stored red blood cells during rest at high altitude and contracts further during exercise, to increase oxygen delivery to tissues during acute hypoxia. The attenuated Hb response to exercise at the highest altitude is likely due to the greater recruitment of the spleen reserve during rest, and that maximal spleen contraction is reached with exercise.
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