Evidence map›Paper›PMID 32910224›Full record

ArticleCellular and molecular life sciences : CMLS2021

FGF primes angioblast formation by inducing ETV2 and LMO2 via FGFR1/BRAF/MEK/ERK.

Peng-Chieh Chen, Ya-Wen Hsueh, Yi-Hsuan Lee, Hung-Wen Tsai, Kuen-Jer Tsai, Po-Min Chiang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Peng-Chieh Chen *Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, No. 35, Xiaodong Rd., Tainan, 70457, Taiwan.
Ya-Wen Hsueh *Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, No. 35, Xiaodong Rd., Tainan, 70457, Taiwan.
Yi-Hsuan LeeDepartment of Pathology, National Taiwan University Hospital, Taipei, Taiwan.
Hung-Wen TsaiDepartment of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Kuen-Jer TsaiInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, No. 35, Xiaodong Rd., Tainan, 70457, Taiwan.
Po-Min ChiangInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, No. 35, Xiaodong Rd., Tainan, 70457, Taiwan. pchiang@mail.ncku.edu.tw.ORCID http://orcid.org/0000-0002-4950-9292
National Cheng Kung University Hospital · TWNational Taiwan University Hospital · TW

Funding

Ministry of Science and Technology, Taiwan 107-2314-B-006-025Ministry of Science and Technology, Taiwan 108-2320-B-006-028Ministry of Science and Technology, Taiwan 109-2320-B-006-029
6 · The paper itself

Abstract

It is critical to specify a signal that directly drives the transition that occurs between cell states. However, such inferences are often confounded by indirect intercellular communications or secondary transcriptomic changes due to primary transcription factors. Although FGF is known for its importance during mesoderm-to-endothelium differentiation, its specific role and signaling mechanisms are still unclear due to the confounding factors referenced above. Here, we attempted to minimize the secondary artifacts by manipulating FGF and its downstream mediators with a short incubation time before sampling and protein-synthesis blockage in a low-density angioblastic/endothelial differentiation system. In less than 8 h, FGF started the conversion of KDR

Indexed as

Adaptor Proteins, Signal TransducingBlood VesselsCell DifferentiationCell LineFibroblast Growth FactorsHumansLIM Domain ProteinsMAP Kinase Signaling SystemMesodermProto-Oncogene ProteinsProto-Oncogene Proteins B-rafReceptor, Fibroblast Growth Factor, Type 1Transcription FactorsVascular Endothelial Growth Factor AAdaptor Proteins, Signal TransducingBRAF protein, humanETV2 protein, humanFibroblast Growth FactorsLIM Domain ProteinsLMO2 protein, humanProto-Oncogene ProteinsProto-Oncogene Proteins B-rafReceptor, Fibroblast Growth Factor, Type 1Transcription FactorsVascular Endothelial Growth Factor AAngioblastsEndotheliumETV2FGFFGFR1/BRAF/MEK/ERKLMO2Low-density and defined differentiation systemMesoderm

Identifiers

PMID32910224
PMCPMC11073248
OpenAlexW3084682159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.