ArticleCurrent microbiology2020
Inhibitory Effect of Phenolic Acids in Rubus coreanus on Glucosyltransferase of Streptococcus mutans.
Article in Current microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Synergistic Antimicrobial and Antibiofilm Activity Optimization of aMicroorganisms · 2026Article
- Chemical composition, pharmacological activity and development strategies ofChinese herbal medicines · 2024Review
- Synergistic inhibitory activity of Glycyrrhizae Radix and Rubi Fructus extracts on biofilm formation of Streptococcus mutans.BMC complementary medicine and therapies · 2023Article
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Streptococcus mutans, a typical dental caries-causing oral pathogen, forms dental biofilm by attaching to the surface of teeth. Its glucosyltransferase (GTFase) is responsible for synthesizing water-insoluble glucan from sucrose, which is an important factor for biofilm formation and for providing microbial resistance against stresses. Therefore, inhibiting the activity of GTFase is an effective approach to prevent the formation of dental biofilm even without killing S. mutans. In this study, we found that 2.5 mg/mL of methanol extracts of Camellia sinensis leaf, Diospyros kaki leaf, Nelumbo nucifera seed, Rubus coreanus fruit, and Ulmus davidiana rhizodermis inhibits both GTFase activity and biofilm formation of S. mutans without affecting cell growth. Phenolic acids such as ferulic acid, salicylic acid, and vanillic acid in R. coreanus fruit extract inhibited GTFase activity. Enzyme kinetic analysis shows that ferulic acid, salicylic acid, and vanillic acid are competitive, noncompetitive, and uncompetitive inhibitors, respectively. These results suggest that R. coreanus fruit extracts containing phenolic acids may control and prevent dental caries without killing S. mutans by inhibiting GTFase activity.
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