ArticleRheumatology (Oxford, England)2021
Muscle deterioration due to rheumatoid arthritis: assessment by quantitative MRI and strength testing.
Article in Rheumatology (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06400316 (Preventing Muscle Wasting During Rheumatoid Arthritis Flares), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Preventing Muscle Wasting During Rheumatoid Arthritis Flares: A Randomised Controlled Trial
Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Biopsychosocial model-based exercise improves muscle strength, proprioception, pain, function, and quality of life in rheumatoid arthritis patients with knee involvement: a randomized controlled clinical tiral.Rheumatology international · 2025Trial
- Ultrasound viscoelasticity and attenuation imaging for rheumatoid arthritis-associated muscle quality changes: a clinical transcriptomic study.Clinical rheumatology · 2026Article
- Muscle morphology changes over 1-year in patients with rheumatoid arthritis: a prospective cohort study using muscle ultrasound.Advances in rheumatology (London, England) · 2026Observational
- Usnic acid attenuates inflammation and joint damage in Freund's complete adjuvant-induced arthritis in rats.Inflammopharmacology · 2026Article
- Comparison of Lower Extremity Muscle Deterioration in Women with Rheumatoid Arthritis and Healthy Controls: Relationship with Disease Activity, Muscle Strength, and Walking Speed.The Eurasian journal of medicine · 2026Article
- nnUnet-based automated quantification of wrist joint synovitis volume in patients with rheumatoid arthritis: a feasibility study.Radiology advances · 2026Article
- Transcending aging: disease specificity, assessment challenges, and management strategies for rheumatoid arthritis-related sarcopenia.Frontiers in medicine · 2026Review
- Multimodal ultrasound in the assessment of muscle involvement in systemic sclerosis patients: results from a bicentric study.Rheumatology (Oxford, England) · 2025Article
- Health-enhancing physical activity induce beneficial skeletal muscle mitochondrial adaptations in individuals with rheumatoid arthritis.Clinical rheumatology · 2025Article
- Quinic acid alleviates inflammatory responses and oxidative stress in Freund's complete adjuvant-induced arthritic rat model and associated risk factors of atherosclerosis.Inflammopharmacology · 2025Article
- Respiratory Muscle Strength in Rheumatoid Arthritis.Journal of clinical medicine · 2025Article
- Muscle health in ankylosing spondylitis: effects of disease duration, inflammation, education level, and spinal mobility on skeletal muscle atrophy.Therapeutic advances in musculoskeletal disease · 2025Article
- Longitudinal monitoring of handgrip strength in rheumatoid arthritis: a window into for disease activity-a systematic review with meta-analysis.BMJ open sport & exercise medicine · 2025Article
- Cachexia in preclinical rheumatoid arthritis: Longitudinal observational study of thigh magnetic resonance imaging from osteoarthritis initiative cohort.Journal of cachexia, sarcopenia and muscle · 2024Observational
- Red blood cell metabolomics identify ergothioneine as a key metabolite in DMARD-naïve rheumatoid arthritis and response to methotrexate.Scientific reports · 2024Article
- Prevalence and Factors Associated with Sarcopenia in Post-Menopausal Women with Rheumatoid Arthritis.Mediterranean journal of rheumatology · 2024Article
- Investigating the therapeutic potential of sinomenine in rheumatoid arthritis: anti-inflammatory, antioxidant, and immunomodulatory mechanisms.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Sarcopenia in rheumatic disorders: what the radiologist and rheumatologist should know.Skeletal radiology · 2022Review
- Therapeutic Benefit in Rheumatoid Cachexia Illustrated Using a Novel Primary Human Triple Cell Coculture Model.International journal of inflammation · 2022Article
- Structural and Functional Changes of Hands and Legs in Early Rheumatoid Arthritis.Medicina (Kaunas, Lithuania) · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesRA patients often present with low muscle mass and decreased strength. Quantitative MRI offers a non-invasive measurement of muscle status. This study assessed whether MRI-based measurements of T2, fat fraction, diffusion tensor imaging and muscle volume can detect differences between the thigh muscles of RA patients and healthy controls, and assessed the muscle phenotype of different disease stages.
methodsThirty-nine RA patients (13 'new RA'-newly diagnosed, treatment naïve, 13 'active RA'-persistent DAS28 >3.2 for >1 year, 13 'remission RA'-persistent DAS28 <2.6 for >1 year) and 13 age and gender directly matched healthy controls had an MRI scan of their dominant thigh. All participants had knee extension and flexion torque and grip strength measured.
resultsMRI T2 and fat fraction were higher in the three groups of RA patients compared with healthy controls in the thigh muscles. There were no clinically meaningful differences in the mean diffusivity. The muscle volume, handgrip strength, knee extension and flexion were lower in all three groups of RA patients compared with healthy controls.
conclusionQuantitative MRI and muscle strength measurements can potentially detect differences within the muscles between RA patients and healthy controls. These differences may be seen in RA patients who are yet to start treatment, those with persistent active disease, and those who were in clinical remission. This suggests that the muscles in RA patients are affected in the early stages of the disease and that signs of muscle pathology and muscle weakness are still observed in clinical remission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.