ArticleeLife2020
Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Enabling artificial placenta cannulation: mechanisms of postnatal umbilical vessel closure and strategies to prolong patency.Frontiers in physiology · 2026Review
- A functional shunt in the umbilical cord: the role of coiling in solute and heat transfer.Journal of the Royal Society, Interface · 2025Article
- Feto-placental blood vessel development.Development (Cambridge, England) · 2025Review
- Origin and flow-mediated remodeling of the murine and human extraembryonic circulation systems.Frontiers in physiology · 2024Review
- Aggrecan accumulates at sites of increased pulmonary arterial pressure in idiopathic pulmonary arterial hypertension.Pulmonary circulation · 2023Article
- The mouse allantois: new insights at the embryonic-extraembryonic interface.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Keratin filaments mediate the expansion of extra-embryonic membranes in the post-gastrulation mouse embryo.The EMBO journal · 2022Article
- Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organ.Glycobiology · 2021Article
- A new mouse mutant with cleavage-resistant versican and isoform-specific versican mutants demonstrate that proteolysis at the GluMatrix biology plus · 2021Article
- The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1Matrix biology : journal of the International Society for Matrix Biology · 2021Article
- The National Children's Study Archive Model: A 3-Tier Framework for Dissemination of Data and Specimens for General Use and Secondary Analysis.Frontiers in public health · 2021Article
- Aggrecan in Cardiovascular Development and Disease.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020Review
- Severing umbilical ties.eLife · 2020Article
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17 authors at 7 institutions in 3 countries.
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Abstract
The umbilical artery lumen closes rapidly at birth, preventing neonatal blood loss, whereas the umbilical vein remains patent longer. Here, analysis of umbilical cords from humans and other mammals identified differential arterial-venous proteoglycan dynamics as a determinant of these contrasting vascular responses. The umbilical artery, but not the vein, has an inner layer enriched in the hydrated proteoglycan aggrecan, external to which lie contraction-primed smooth muscle cells (SMC). At birth, SMC contraction drives inner layer buckling and centripetal displacement to occlude the arterial lumen, a mechanism revealed by biomechanical observations and confirmed by computational analyses. This vascular dimorphism arises from spatially regulated proteoglycan expression and breakdown. Mice lacking aggrecan or the metalloprotease ADAMTS1, which degrades proteoglycans, demonstrate their opposing roles in umbilical vascular dimorphism, including effects on SMC differentiation. Umbilical vessel dimorphism is conserved in mammals, suggesting that differential proteoglycan dynamics and inner layer buckling were positively selected during evolution.
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