SynthesisCanadian journal of psychiatry. Revue canadienne de psychiatrie2021
Cannabis Use and Prospective Long-Term Association with Anxiety: A Systematic Review and Meta-Analysis of Longitudinal Studies: Usage du cannabis et association prospective à long terme avec l'anxiété: une revue systématique et une méta-analyse d'études longitudinales.
Synthesis in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Balancing risks and benefits of cannabis use: umbrella review of meta-analyses of randomised controlled trials and observational studies.BMJ (Clinical research ed.) · 2023Pooled it
- Unhealthy behaviors associated with mental health disorders: a systematic comparative review of diet quality, sedentary behavior, and cannabis and tobacco use.Frontiers in public health · 2023Pooled it
- Cannabinoid modulation of central amygdala population dynamics during threat investigation.Nature communications · 2026Article
- The role of perceived access to cannabis in the association between friends who use cannabis and adolescent initiation: A longitudinal analysis from the Canadian COMPASS study.Addiction (Abingdon, England) · 2026Observational
- Ecological momentary insights into cannabis use and its contexts: a pre-post legalization study in Germany.Scientific reports · 2026Article
- Beyond the Diagnostic Binary: A Translational Use of the Research Domain Criteria to Improve the Measurement of Anxiety in the Context of Cannabis Use.Healthcare (Basel, Switzerland) · 2026Article
- Beyond cannabis use severity: associations of cannabis product type with sleep quality and mental health.Psychopharmacology · 2026Article
- Trends in the diagnostic prevalence of cannabis-related disorders and co-occurring psychiatric disorders in adolescents: analysis of German health insurance data from 2013 to 2022.European journal of public health · 2026Article
- Direct modulation of human GABA-A αFrontiers in neuroscience · 2026Review
- Centering Individuals With Mental Illness as an At-Risk Group in the Era of Cannabis Legalization and Commercialization.Clinical therapeutics · 2026Article
- Cannabis Use During Early Pregnancy and Child Diagnoses of Depressive and Anxiety Disorders.Cannabis (Albuquerque, N.M.) · 2026Article
- Cannabis Use Disorder in the Era of Legalization: Implications for Addiction Treatment Systems.Substance abuse and rehabilitation · 2026Review
- Are reasons for first using cannabis associated with subsequent cannabis consumption (standard THC units) and psychopathology?BMJ mental health · 2025Article
- Use of Tobacco and Cannabis Following State-Level Cannabis Legalization.JAMA network open · 2025Article
- Cannabis, cannabinoids and health: a review of evidence on risks and medical benefits.European archives of psychiatry and clinical neuroscience · 2025Review
- Reducing medical cannabis use risk among Veterans: A descriptive study.Harm reduction journal · 2025Article
- Cannabinoids for treating psychiatric disorders in youth: a systematic review of randomized controlled trials.Child and adolescent psychiatry and mental health · 2024Review
- Reducing the harms of cannabis use in youth post-legalization: insights from Ontario youth, parents, and service providers.Harm reduction journal · 2024Article
- Disproportionate increase in cannabis use among people with serious psychological distress and associations with psychiatric service use in the United States, 2009-2019.Addictive behaviors · 2024Article
- Understanding youth and young adult cannabis use in Canada post-legalization: a scoping review on a public health issue.Substance abuse treatment, prevention, and policy · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesCannabis use is proposed as a risk factor for psychosis and is associated with depressive disorders. However, the relationship between recreational cannabis use and its longitudinal implications on anxiety conditions is less studied. The aim of this investigation is to systematically evaluate published literature and perform a meta-analysis of the data.
methodsA systematic search was performed of MEDLINE, Embase, and PsychINFO from inception to May 31, 2020, in addition to a hand search. Longitudinal studies that evaluated the relationship of cannabis use and development of anxiety were included. Where applicable, adjusted odds ratios (
resultsAfter screening of unique abstracts (
conclusionsPublished evidence suggests that cannabis use is likely associated with increased risk of anxiety in the long term but variability of study designs precludes declaration of a causal relationship. Awareness of this association is of relevance for both clinical practice and mental health policy implementation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.