ArticleBrain and behavior2020
Alteration in topological properties of brain functional network after 2-year high altitude exposure: A panel study.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Effects of long-term exposure to high altitude on brain structure in healthy people: an MRI-based systematic review and meta-analysis.Frontiers in psychiatry · 2023Pooled it
- Chronic high-altitude exposure and cognitive health in Chinese college students: a 4-year longitudinal neuroimaging study.Scientific reports · 2026Article
- Reversible brain functional alterations induced by Short-Term high altitude exposure.Brain imaging and behavior · 2026Article
- Effects of Kuanxiong aerosol for preventing acute mountain sickness: an exploratory small-sample randomized, placebo-controlled trial.Frontiers in physiology · 2026Article
- Alterations in static and dynamic topological properties of brain functional network after chronic high altitude exposure: a panel study.Frontiers in aging neuroscience · 2026Article
- Hypoxia's Impact on Hippocampal Functional Connectivity: Insights from Resting-State fMRI Studies.Brain sciences · 2025Review
- High-altitude exposure leads to increased modularity of brain functional network with the increased occupation of attention resources in early processing of visual working memory.Cognitive neurodynamics · 2024Article
- A review of methods for assessment of cognitive function in high-altitude hypoxic environments.Brain and behavior · 2024Review
- Consistent differences in brain structure and functional connectivity in high-altitude native Tibetans and immigrants.Brain imaging and behavior · 2023Article
- Article
- The human brain in a high altitude natural environment: A review.Frontiers in human neuroscience · 2022Review
- Topological Abnormalities of Pallido-Thalamo-Cortical Circuit in Functional Brain Network of Patients With Nonchemotherapy With Non-small Cell Lung Cancer.Frontiers in neurology · 2022Article
- Altered Degree Centrality of Brain Networks in Parkinson's Disease With Freezing of Gait: A Resting-State Functional MRI Study.Frontiers in neurology · 2021Article
- Alteration in topological properties of brain functional network after 2-year high altitude exposure: A panel study.Brain and behavior · 2020Article
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Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
introductionHigh altitude (HA) exposure leads to cognitive impairment while the underlying mechanism is still unclear. Brain functional network is crucial for advanced functions, and its alteration is implicated in cognitive decline in multiple diseases. The aim of current study was to investigate the topological changes in HA-exposed brain functional network.
methodsBased on Shaanxi-Tibet immigrant cohort, neuropsychological tests and resting-state functional MRI were applied to evaluate the participants' cognitive function and functional connection (FC) changes, respectively. GRETNA toolbox was used to construct the brain functional network. The gray matter was parcellated into 116 anatomically defined regions according to Automated Anatomical Labeling atlas. Subsequently, the mean time series for each of the 116 regions were extracted and computed for Pearson's correlation coefficients. The relation matrix was further processed and seen as brain functional network. Correlation between functional network changes and neuropsychological results was also examined.
resultsThe cognitive performance was impaired by HA exposure as indicated by neuropsychological test. HA exposure led to alterations of degree centrality and nodal efficiency in multiple brain regions. Moreover, two subnetworks were extracted in which the FCs significantly decreased after exposure. In addition, the alterations in FCs within above two subnetworks were significantly correlated with changes of memory and reaction time.
conclusionsOur results suggest that HA exposure modulates the topological property of functional network and FCs of some important regions, which may impair the attention, perception, memory, motion ignition, and modulation processes, finally decreasing cognitive performance in neuropsychological tests.
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