Underrepresentation of the elderly in clinical trials, time for action.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

78 citing papers in PubMed, 10 syntheses or guidelines pooled it.

1. The views of healthcare professionals and family members on deprescribing preventive medication in people living with dementia: a qualitative systematic review.BMC geriatrics · 2026
   Pooled it
2. Safety and Efficacy of Sodium-Glucose Cotransporter 2 Inhibitors in Older Adults with Variable Disease States: A Meta-analysis of Large Placebo-Controlled Trials.Drugs & aging · 2025
   Pooled it
3. Lenvatinib plus pembrolizumab for untreated advanced renal cell carcinoma: a systematic review and cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2024
   Pooled it
4. Frequency of use and characterization of frailty assessments in observational studies on older women with breast cancer: a systematic review.BMC geriatrics · 2024
   Pooled it
5. Trends in Patient Representation in Low Back Pain Pharmacological Randomized Clinical Trials, 2011 to 2020: A Systematic Review.The journal of pain · 2024
   Pooled it
6. Immunotherapy in elderly head and neck cancer patients: a systematic review and meta-analysis.Frontiers in oncology · 2024
   Pooled it
7. Temporal changes in characteristics and external validity of randomized controlled trials in older people from 2012 to 2019.BMC geriatrics · 2023
   Pooled it
8. Age-based exclusion is common and multifactorial in spinal RCTs: a systematic review and quantitative analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023
   Pooled it
9. What is the prevalence of fear of cancer recurrence in cancer survivors and patients? A systematic review and individual participant data meta-analysis.Psycho-oncology · 2022
   Pooled it
10. Vaccination uptake amongst older adults from minority ethnic backgrounds: A systematic review.PLoS medicine · 2021
    Pooled it
11. Nurse-led secondary preventive follow-up after stroke/TIA and ACS for patients aged 80 years or older: A post-hoc analysis of the randomized controlled NAILED trial.PloS one · 2025
    Trial
12. The Invisible Barrier of Neighborhood Disadvantage in Clinical Trial Recruitment and Retention Among Older Adults.Journal of the American Geriatrics Society · 2026
    Article
13. Safety of SGLT2 inhibitors versus DPP-4 inhibitors in super-elderly patients (≥ 80 years) with type 2 diabetes: a propensity score-matched cohort study.Cardiovascular diabetology. Endocrinology reports · 2026
    Article
14. Widespread inappropriate prescribing for older people with reduced kidney function: what are the harms and how do we tackle them? A scoping review for primary care.BMJ quality & safety · 2026
    Article
15. Barriers and facilitators to recruiting older adult care home residents into clinical trials of medicines and vaccines: a scoping review.Age and ageing · 2026
    Article
16. Patient-reported geriatric syndromes and their association with quality of life: findings from a cross-sectional study in German older adults.European geriatric medicine · 2026
    Article
17. Cardiac Synchrony During Collaborative Drawing: A Longitudinal Comparison of Same Generation and Intergenerational Dyads.Annals of the New York Academy of Sciences · 2026
    Article
18. Trends and Predictors of Premature Termination of Cardiovascular Trials: A Systematic Review.JACC. Advances · 2026
    Article
19. Tumor biology, treatment patterns, and recurrence in breast cancer patients aged 70-79 vs ≥ 80 years: a large-scale registry analysis.Archives of gynecology and obstetrics · 2026
    Article
20. Embracing the Digital Revolution: How Artificial Intelligence is Transforming Clinical Trials in Older Participants.Drugs & aging · 2026
    Review

18 more citing papers are in PubMed but not listed here.

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as