Evidence map›Paper›PMID 32909218›Full record

Trial reportThe patient2021

Patient Perspectives of Quality of the Same-Day Antiretroviral Therapy Initiation Process in Gauteng Province, South Africa: Qualitative Dominant Mixed-Methods Analysis of the SLATE II Trial.

Nancy A Scott, Mhairi Maskew, Rachel M Fong, Ingrid E Olson, Alana T Brennan, Matthew P Fox, Lungisile Vezi, Peter D Ehrenkranz, Sydney Rosen

Registry-linked trialAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in The patient, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03315013 (Randomized Evaluation of a Revised, Simplified Clinical Algorithm for Identifying Patients Eligible for Immediate Initiation of Antiretroviral Therapy for HIV), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03315013 nacompletednot on this map

Randomized Evaluation of a Revised, Simplified Clinical Algorithm for Identifying Patients Eligible for Immediate Initiation of Antiretroviral Therapy for HIV (SLATEII)

TypeinterventionalSponsorBoston UniversityRan2018 to 2020Enrolled600ConditionsHIV/AIDS, Antiretroviral TherapyArmsSLATE II
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nancy A ScottDepartment of Global Health, Boston University School of Public Health, 801 Massachusetts Ave 3rd Floor, Boston, MA, 02118, USA. nscott@bu.edu.ORCID 0000-0002-4713-4642
Mhairi MaskewHealth Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Rachel M FongDepartment of Global Health, Boston University School of Public Health, 801 Massachusetts Ave 3rd Floor, Boston, MA, 02118, USA.
Ingrid E OlsonDepartment of Global Health, Boston University School of Public Health, 801 Massachusetts Ave 3rd Floor, Boston, MA, 02118, USA.
Alana T BrennanDepartment of Global Health, Boston University School of Public Health, 801 Massachusetts Ave 3rd Floor, Boston, MA, 02118, USA.
Matthew P FoxDepartment of Global Health, Boston University School of Public Health, 801 Massachusetts Ave 3rd Floor, Boston, MA, 02118, USA.
Lungisile VeziHealth Economics and Epidemiology Research Office, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Peter D EhrenkranzBill & Melinda Gates Foundation, Seattle, WA, USA.
Sydney RosenDepartment of Global Health, Boston University School of Public Health, 801 Massachusetts Ave 3rd Floor, Boston, MA, 02118, USA.

Funding

Bill & Melinda Gates Foundation OPP1136158
6 · The paper itself

Abstract

backgroundHIV patients in South Africa continue to report operational barriers to starting antiretroviral therapy (ART). In the Simplified Algorithm for Treatment Eligibility (SLATE) II trial, same-day initiation (SDI) of ART increased the number of patients commencing ART and achieving HIV viral suppression by using a screening tool to distinguish between patients eligible for SDI and those requiring additional care before starting treatment. We conducted a mixed-methods evaluation to explore trial patients' perceptions and experiences of SDI.

methodsSLATE II was implemented at three urban, public primary health care clinics in Gauteng Province, South Africa. We conducted a short quantitative survey and in-depth interviews among a purposive sample of 89 of the 593 trial participants in the intervention and standard arms, using a mixed inductive-deductive framework approach.

resultsNearly all respondents (95%) were satisfied with their care, despite reporting clinic wait times of ≥ 3 h (72%). Intervention patients found the initiation process to be easy; standard patients found it complicated and were frustrated with being shuffled around the clinic. No intervention arm patients felt that SDI was "too fast" or indicated a preference for a more gradual process. Both groups highlighted the need for good counselling and non-judgmental, respectful staff. Standard patients suggested improving patient-provider relations, strengthening counselling, reducing wait times, and minimising referrals.

conclusionsWhile it is difficult to untangle the role of providers from that of the SLATE algorithm in influencing patient experiences, adoption of SLATE II implementation procedures could improve patient experience of treatment initiation.

trial registrationClinicaltrials.gov NCT03315013, registered October 19, 2017.

Indexed as

Anti-HIV AgentsHIV InfectionsAlgorithmsCounselingEligibility DeterminationHumansSouth AfricaAnti-HIV Agents

Identifiers

PMID32909218
PMCPMC7884580

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.