ArticleClinical and experimental nephrology2020
Intravenous administration of Streptococcus mutans induces IgA nephropathy-like lesions.
Article in Clinical and experimental nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Specific alterations of gut microbiota in patients with membranous nephropathy: A systematic review and meta-analysis.Frontiers in physiology · 2022Pooled it
- cnm-positive Streptococcus mutans is associated with IgA nephropathy: a comparative study among kidney diseases.Clinical and experimental nephrology · 2026Article
- Association between Oral Streptococcus Mutans Counts and Proteinuria in Patients with Chronic Kidney Disease: A Pilot Study Using Chlorhexidine.JMA journal · 2026Article
- Relationship between oral microbiota and chronic kidney disease: facts and perspectives.Journal of oral microbiology · 2026Review
- The oral - X axis: from periodontal dysbiosis to systemic disease.Frontiers in immunology · 2026Review
- cnm-positive Streptococcus mutans, a major pathogen in dental caries, may exacerbate IgA nephropathy via the tonsils.Clinical and experimental nephrology · 2025Article
- Binding of IgA1 and surface-expressed collagen-binding protein ofFrontiers in cellular and infection microbiology · 2025Article
- Gut and respiratory microbiota landscapes in IgA nephropathy: a cross-sectional study.Renal failure · 2024Article
- Contribution of collagen-binding protein Cnm of Streptococcus mutans to induced IgA nephropathy-like nephritis in rats.Communications biology · 2024Article
- Porphyromonas gingivalis infection in the oral cavity is associated with elevated galactose-deficient IgA1 and increased nephritis severity in IgA nephropathy.Clinical and experimental nephrology · 2024Article
- Mechanisms that potentially contribute to the development of post-streptococcal glomerulonephritis.Pathogens and disease · 2024Review
- cnm-positive Streptococcus mutans is associated with galactose-deficient IgA in patients with IgA nephropathy.PloS one · 2023Article
- Title IgA Nephropathy and Oral Bacterial Species Related to Dental Caries and Periodontitis.International journal of molecular sciences · 2022Review
- Cnm ofFrontiers in cellular and infection microbiology · 2022Article
- Relationship between IgA Nephropathy andInternational journal of molecular sciences · 2021Article
- Streptococcus mutans induces IgA nephropathy-like glomerulonephritis in rats with severe dental caries.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundIgA nephropathy (IgAN) is one of the most frequently occurring types of chronic glomerulonephritis. Previous analyses have revealed that a major pathogen of dental caries, Streptococcus mutans [which expresses collagen-binding protein (Cnm) on its surface], is involved in the pathogenesis of IgAN.
methodsCnm-positive S. mutans isolated from a patient with IgAN was intravenously administered to specific pathogen-free Sprague-Dawley rats to evaluate their kidney conditions.
resultsThe urinary protein level of the S. mutans group reached a plateau at 30 days, with increased numbers of mesangial cells and an increased mesangial matrix. The numbers of rats with IgA-positive and/or C3-positive glomeruli were significantly greater in the S. mutans group than in the control group at 45 days (P < 0.05). Electron microscopy analyses revealed electron-dense depositions in the mesangial area among rats in the S. mutans group. There were significantly more CD68-positive cells (macrophages) in the glomeruli of the S. mutans group than in the glomeruli of the control group during the late phase (P < 0.05), similar to the findings in patients with IgAN.
conclusionOur results suggested that intravenous administration of Cnm-positive S. mutans caused transient induction of IgAN-like lesions in rats.
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