ArticleBreast cancer (Tokyo, Japan)2021
The impact of cognitive impairment on survival and medication adherence among older women with breast cancer.
Article in Breast cancer (Tokyo, Japan), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Frequency of use and characterization of frailty assessments in observational studies on older women with breast cancer: a systematic review.BMC geriatrics · 2024Pooled it
- Construction and Validation of a Risk Prediction Model for Cancer-Related Cognitive Impairment in Lung Cancer Patients.International journal of nursing practice · 2026Observational
- Multilevel Interventions to Improve Medication Adherence in Older Adults: A Systematic Review and Meta-Analysis of Cognitive, Digital, Behavioral, and Socioeconomic Strategies (2015-2025).Journal of clinical medicine · 2026Review
- Cognition and coronary events: A narrative overview of neurocognitive impairment in ACS patients.American heart journal plus : cardiology research and practice · 2025Review
- Association between hippocampal subfield volumes and working memory in middle-aged and older adult cancer patients.Frontiers in human neuroscience · 2025Article
- Social enrichment alters the response of brain leukocytes to chemotherapy and tumor development in aged mice.Heliyon · 2024Article
- Development and efficacy of mobile application to improve medication adherence for persons with cardiac disease.ARYA atherosclerosis · 2024Article
- Remote assessment of cognitive dysfunction in hematologic malignancies using web-based neuropsychological testing.Cancer medicine · 2023Article
- Clinical and genetic factors associated with self-reported cognitive deficits in women with breast cancer: the "CAGE-Cog" study.BMC cancer · 2022Article
- The correlation between neutrophil-to-lymphocyte ratio, carcinoembryonic antigen, and carbohydrate antigen 153 levels with chemotherapy-related cognitive impairment in early-stage breast cancer patients.Frontiers in medicine · 2022Article
- Impact of psychosocial, behavioral and lifestyle factors on subjective cognitive complaints and perceived quality of life in a large cohort of Italian breast cancer patients.Frontiers in psychology · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
introductionThe purpose of this study was to examine the impact of preexisting cognitive impairments on survival and medication adherence, and whether chronic medication adherence mediates or moderates the association between cognitive impairments and mortality in patients with breast cancer.
methodsThis retrospective cohort study of older female patients diagnosed with breast cancer was conducted using the Surveillance, Epidemiology, and End Results Medicare Linked Database. We examined the risk of mortality from cancer and non-cancer causes in patients with and without a history of cognitive impairment. In addition, we examined if chronic medication adherence rates differ between these groups of patients and if medication adherence mediates or moderates the association between cognitive impairments and non-cancer mortality.
resultsMortality from cancer-specific (HR 1.13, 95% CI 1.04-1.23) and non-cancer causes (HR 1.16, 95% CI 1.11-1.21) as well as all-cause mortality (HR 1.30, 95% CI 1.23-1.38) was significantly higher in patients with cognitive impairments compared to those without cognitive impairment. Both groups showed low adherence levels to chronic medication before and after the breast cancer diagnosis. Further analysis did not show that medication adherence mediates or moderates the relationship between cognitive impairment and non-cancer mortality (p value > 0.05).
conclusionThe results of this study indicate that older female patients with cognitive impairments and a breast cancer diagnosis have a heightened risk of cancer-specific and non-cancer mortality. Our findings do not indicate that chronic medication adherence plays a role in the association between a history of cognitive impairment and mortality, it is still necessary to further investigate this issue.
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