ArticlemedRxiv : the preprint server for health sciences2020
Cytotoxic lymphocytes are dysregulated in multisystem inflammatory syndrome in children.
Open access · greenAbstract readPreprint
In one paragraph
Article in medRxiv : the preprint server for health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 16 citations in OpenAlex.
- Factors associated with cycle threshold values (Ct-values) of SARS-CoV2-rRT-PCR.Molecular biology reports · 2022Article
Corrections and comments
- Updated by
Authors and funding
84 authors at 6 institutions in 2 countries.
Noam D BeckmannDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Phillip H ComellaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Esther ChengDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Lauren LepowDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Aviva G BeckmannDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Konstantinos MouskasDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Nicole W SimonsDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Gabriel E HoffmanDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Nancy J FrancoeurDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Diane Marie Del ValleTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Gurpawan KangDepartment of Medicine, division of Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Emily MoyaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Lillian WilkinsDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Jessica Le BerichelTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Christie ChangPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Robert MarvinPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Sharlene CalorossiPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Alona LanskyPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Laura WalkerPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Nancy YiPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Alex YuDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Matthew HartnettIcahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Melody EatonPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Sandra HatemTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Hajra JamalHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Alara AkyatanDepartment of of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Alexandra TabachnikovaHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Lora E LiharskaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Liam CotterDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Brian FennesseyDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Akhil VaidDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Guillermo BarturenDepartment of Medical Genomics, Center for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government (GENYO), 18007 Urb. los Vergeles, Granada, Spain.
Scott R TylerDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Hardik ShahDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Ying-Chih WangDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Shwetha Hara SridharDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Juan SotoDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Swaroop BoseDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Kent MadridDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Ethan EllisDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Elyze MerzierDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Konstantinos VlachosDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Nataly FishmanDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Manying TinDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Melissa SmithDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Hui XiePrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Manishkumar PatelPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Kimberly ArguetaPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Jocelyn HarrisPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Neha KarekarPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Craig BatchelorPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Jose LacunzaPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Mahlet YishakPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Kevin TuballesPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Leisha ScottPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Arvind KumarGraduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Suraj JaladankiDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Ryan ThompsonDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Evan ClarkDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Bojan LosicDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Mount Sinai COVID-19 Biobank Team
Jun ZhuIcahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Wenhui WangIcahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Andrew KasarskisIcahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Benjamin S GlicksbergDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Girish NadkarniMount Sinai COVID Informatics Center, New York, NY 10029, USA.
Dusan BogunovicDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Cordelia ElaihoDepartment of Urology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Sandeep GangadharanDepartments of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
George Ofori-AmanfoDepartments of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kasey Alesso-CarraDepartments of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Kenan OnelDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Karen M WilsonDepartments of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Carmen ArgmannDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Marta E Alarcón-RiquelmeDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Thomas U MarronTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Adeeb RahmanTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Seunghee Kim-SchulzeTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Sacha GnjaticTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Bruce D GelbDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Miriam MeradTisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Robert SebraDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Eric E SchadtDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Alexander W CharneyDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Icahn School of Medicine at Mount Sinai · USNew York Institute of Technology · USMount Sinai Medical Center · USChild Health and Development Institute · USNew York Stem Cell Foundation · USPfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research · ES
Funding
High-Dimensional Immune Monitoring of NCI-Supported Immunotherapy TrialsU24CA224319 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Sacha Gnjatic, Seunghee Kim-Schulze · 2017 to 2026
$21.5MPediatric Heart Disease: Getting from Mutations to TherapeuticsR35HL135742 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GELB, BRUCE D · 2017 to 2023
$6.1MCharacterizing and predicting colitis in immune checkpoint blockade-treated cancer patientsU01DK124165 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI COLOMBEL, JEAN-FREDERIC, FAITH, JEREMIAH JAMES · 2020 to 2024
$2.9MNCI NIH HHS U24 CA224319NHLBI NIH HHS R35 HL135742NIDDK NIH HHS U01 DK124165
Abstract
Multisystem inflammatory syndrome in children (MIS-C) presents with fever, inflammation and multiple organ involvement in individuals under 21 years following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. To identify genes, pathways and cell types driving MIS-C, we sequenced the blood transcriptomes of MIS-C cases, pediatric cases of coronavirus disease 2019, and healthy controls. We define a MIS-C transcriptional signature partially shared with the transcriptional response to SARS-CoV-2 infection and with the signature of Kawasaki disease, a clinically similar condition. By projecting the MIS-C signature onto a co-expression network, we identified disease gene modules and found genes downregulated in MIS-C clustered in a module enriched for the transcriptional signatures of exhausted CD8
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.