Evidence map›Paper›PMID 32909002›Full record

ArticlemedRxiv : the preprint server for health sciences2020

Limited intestinal inflammation despite diarrhea, fecal viral RNA and SARS-CoV-2-specific IgA in patients with acute COVID-19.

Graham J Britton, Alice Chen-Liaw, Francesca Cossarini, Alexandra E Livanos, Matthew P Spindler, Tamar Plitt, Joseph Eggers, Ilaria Mogno, Ana S Gonzalez-Reiche, Sophia Siu and 17 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 36 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 1 institution in 1 country.

Graham J BrittonPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Alice Chen-LiawPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Francesca CossariniPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Alexandra E LivanosPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Matthew P SpindlerPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Tamar PlittPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Joseph EggersDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Ilaria MognoPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Ana S Gonzalez-ReicheIcahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029.
Sophia SiuPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Michael TankelevichPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Lauren Tal GrinspanThe Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Rebekah E DixonThe Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Divya JhaPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Adriana van de GuchteIcahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029.
Zenab KhanIcahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029.
Gustavo Martinez-DelgadoPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Fatima AmanatDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Daisy A HoaglandDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Benjamin R tenOeverDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Marla C DubinskyThe Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Miriam MeradPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Harm van BakelIcahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029.
Florian KrammerDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Gerold BongersDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Saurabh MehandruPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Jeremiah J FaithPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Icahn School of Medicine at Mount Sinai · US

Funding

COLLABORATIVE INFLUENZA VACCINE INNOVATION CENTER: UNIVERSAL INFLUENZA VACCINE RESEARCH75N93019C00051 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KRAMMER, FLORIAN · 2019 to 2025
$105.4M
The Influence Of Gut Microbiota Stability In Inflammatory Bowel DiseaseR01DK112978 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Jeremiah James Faith · 2019 to 2026
$5.3M
Determination of mucosal immune responses to, and infection of the gastrointestinal tract by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)R01DK123749 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CERUTTI, ANDREA, FAITH, JEREMIAH JAMES · 2020 to 2024
$4.9M
Uncovering the rules of gut microbiome strain transmissionR01DK124133 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Jeremiah James Faith · 2020 to 2026
$4.2M
Immunology Training GrantT32AI007605 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI LIRA, SERGIO A. · 2001 to 2017
$2.2M
Big Omics Data Engine 2 SupercomputerS10OD026880 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2019 to 2019
$2.0M
Transforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9M
The relationship between host diet, the gut microbiota, and host transcriptionR01GM108505 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FAITH, JEREMIAH JAMES · 2014 to 2017
$1.7M
NIAID NIH HHS 75N93019C00051NIAID NIH HHS HHSN272201400008CNIAID NIH HHS T32 AI007605NIDDK NIH HHS R01 DK112978NIDDK NIH HHS R01 DK123749NIDDK NIH HHS R01 DK124133NIGMS NIH HHS R01 GM108505NIH HHS S10 OD018522NIH HHS S10 OD026880
6 · The paper itself

Abstract

We sought to characterize the role of the gastrointestinal immune system in the pathogenesis of the inflammatory response associated with COVID-19. We measured cytokines, inflammatory markers, viral RNA, microbiome composition and antibody responses in stool from a cohort of 44 hospitalized COVID-19 patients. SARS-CoV-2 RNA was detected in stool of 41% of patients and more frequently in patients with diarrhea. Patients who survived had lower fecal viral RNA than those who died. Strains isolated from stool and nasopharynx of an individual were the same. Compared to uninfected controls, COVID-19 patients had higher fecal levels of IL-8 and lower levels of fecal IL-10. Stool IL-23 was higher in patients with more severe COVID-19 disease, and we found evidence of intestinal virus-specific IgA responses associated with more severe disease. We provide evidence for an ongoing humeral immune response to SARS-CoV-2 in the gastrointestinal tract, but little evidence of overt inflammation.

Identifiers

PMID32909002
PMCPMC7480054
OpenAlexW3083058024

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.