Evidence map›Paper›PMID 32908918›Full record

ArticleBioMed research international2020

Alteration of Intestinal Microbiota in 3-Deoxyglucosone-Induced Prediabetic Rats.

Jin Cai, Liang Zhou, Xiudao Song, Meiqi Yin, Guoqiang Liang, Heng Xu, Lurong Zhang, Guorong Jiang, Fei Huang

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
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  10. Gut microbiota and acne: A Mendelian randomization study.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023
    Article
  11. Review
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  13. Gut bacteria of adult and larvalFrontiers in microbiology · 2023
    Article
  14. Article
  15. Article
  16. Differential effects ofFrontiers in endocrinology · 2022
    Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jin CaiClinical Pharmaceutical Laboratory of Traditional Chinese Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009 Jiangsu, China.ORCID https://orcid.org/0000-0001-7027-2421
Liang ZhouClinical Pharmaceutical Laboratory of Traditional Chinese Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009 Jiangsu, China.ORCID https://orcid.org/0000-0003-0188-2044
Xiudao SongClinical Pharmaceutical Laboratory of Traditional Chinese Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009 Jiangsu, China.ORCID https://orcid.org/0000-0003-1615-7996
Meiqi YinClinical Pharmaceutical Laboratory of Traditional Chinese Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009 Jiangsu, China.
Guoqiang LiangClinical Pharmaceutical Laboratory of Traditional Chinese Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009 Jiangsu, China.ORCID https://orcid.org/0000-0002-2355-444X
Heng XuClinical Pharmaceutical Laboratory of Traditional Chinese Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009 Jiangsu, China.
Lurong ZhangClinical Pharmaceutical Laboratory of Traditional Chinese Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009 Jiangsu, China.ORCID https://orcid.org/0000-0002-0829-4942
Guorong JiangClinical Pharmaceutical Laboratory of Traditional Chinese Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009 Jiangsu, China.ORCID https://orcid.org/0000-0001-5736-2270
Fei HuangClinical Pharmaceutical Laboratory of Traditional Chinese Medicine, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, 215009 Jiangsu, China.ORCID https://orcid.org/0000-0001-9580-7808
Nanjing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our previous research suggests that 3-deoxyglucosone (3DG), formed in the caramelization course and Maillard reactions in food, is an independent factor for the development of prediabetes. Since the relationship between type 2 diabetes (T2D) and intestinal microbiota is moving from correlation to causality, we investigated the alterations in the composition and function of the intestinal microbiota in 3DG-induced prediabetic rats. Rats were given 50 mg/kg 3DG by intragastric administration for two weeks. Microbial profiling in faeces samples was determined through the 16S rRNA gene sequence. The glucagon-like peptide 2 (GLP-2) and lipopolysaccharide (LPS) levels in plasma and intestinal tissues were measured by ELISA and Limulus test, respectively. 3DG treatment did not significantly change the richness and evenness but affected the composition of intestinal microbiota. At the phylum level, 3DG treatment increased the abundance of nondominant bacteria

Indexed as

Administration, OralAnimalsDeoxyglucoseGastrointestinal MicrobiomeGlucagon-Like Peptide 2Glucose Tolerance TestLipopolysaccharidesMalePrediabetic StateRats, Sprague-DawleyRNA, Ribosomal, 16S3-deoxyglucosoneDeoxyglucoseGlucagon-Like Peptide 2LipopolysaccharidesRNA, Ribosomal, 16S

Identifiers

PMID32908918
PMCPMC7468600
OpenAlexW3081366339

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.