Evidence map›Paper›PMID 32908884›Full record

ArticleBioMed research international2020

A Modified Murine Calvarial Osteolysis Model Exposed to Ti Particles in Aseptic Loosening.

Zhantao Deng, Shuai Wang, Mengyuan Li, Guangtao Fu, Chang Liu, Shuxian Li, Jiewen Jin, Feng-Juan Lyu, Yuanchen Ma, Qiujian Zheng

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Zhantao DengDepartment of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.ORCID https://orcid.org/0000-0003-0316-234X
Shuai WangDepartment of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.ORCID https://orcid.org/0000-0002-9869-3583
Mengyuan LiDepartment of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.ORCID https://orcid.org/0000-0002-1046-5122
Guangtao FuDepartment of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Chang LiuSouth China University of Technology-The University of Western Australia Joint Center for Regenerative Medicine Research, School of Medicine, South China University of Technology, Guangzhou 510641, China.ORCID https://orcid.org/0000-0002-9118-2422
Shuxian LiDepartment of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.ORCID https://orcid.org/0000-0003-4705-9539
Jiewen JinDepartment of Endocrinology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.ORCID https://orcid.org/0000-0001-9678-701X
Feng-Juan LyuSouth China University of Technology-The University of Western Australia Joint Center for Regenerative Medicine Research, School of Medicine, South China University of Technology, Guangzhou 510641, China.ORCID https://orcid.org/0000-0002-2112-194X
Yuanchen MaDepartment of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.ORCID https://orcid.org/0000-0003-0490-3744
Qiujian ZhengDepartment of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.ORCID https://orcid.org/0000-0002-3078-6601
Guangdong Academy of Medical Sciences · CNThe University of Western Australia · AUSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the different effects on osteolysis between commercial pure Ti particles and TiAl6V4 particles obtained from prosthesis of patients with aseptic loosening.

methodScanning electron microscope, energy dispersive X-ray spectrometry, and X-ray diffraction were used for the size test, chemical composition test, and phase analysis of two kinds of Ti particles. Microcomputed tomography (micro-CT) and 3-dimensional reconstruction analysis were applied to analyze the bone loss quantitatively and radiologically. Hematoxylin-eosin (HE) staining and tartrate-resistant acid phosphatase (TRAP) staining were used to assess the histologic difference.

resultTiAl6V4 particles were constituted by FeO, Al

conclusionA mouse calvarial model is the most effective animal model for the primary in vivo research of aseptic loosening. Compared with commercial Ti particles, TiAl6V4 particles derived from prosthesis of an aseptic loosening patient had more severe bone loss and more activated osteoclast, which was more consistent with pathogenesis of aseptic loosening

Indexed as

AnimalsArthroplasty, ReplacementDisease Models, AnimalMice, Inbred C57BLOsteolysisProsthesis FailureSkullSpectrometry, X-Ray EmissionTitaniumX-Ray DiffractionX-Ray MicrotomographyTitanium

Identifiers

PMID32908884
PMCPMC7468620
OpenAlexW3080192597

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.