Evidence map›Paper›PMID 32908817›Full record

ArticleWorld journal of orthopedics2020

Oxysterols as promising small molecules for bone tissue engineering: Systematic review.

Ethan Cottrill, Julianna Lazzari, Zach Pennington, Jeff Ehresman, Andrew Schilling, Naomi Dirckx, Nicholas Theodore, Daniel Sciubba, Timothy Witham

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of orthopedics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ethan CottrillDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States. ecottri1@jhmi.edu.
Julianna LazzariDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Zach PenningtonDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Jeff EhresmanDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Andrew SchillingDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Naomi DirckxDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Nicholas TheodoreDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Daniel SciubbaDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Timothy WithamDepartment of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, United States.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBone tissue engineering is an area of continued interest within orthopaedic surgery, as it promises to create implantable bone substitute materials that obviate the need for autologous bone graft. Recently, oxysterols - oxygenated derivatives of cholesterol - have been proposed as a novel class of osteoinductive small molecules for bone tissue engineering. Here, we present the first systematic review of the

aimTo systematically review the available literature examining the effect of oxysterols on

methodsWe conducted a systematic review of the literature following PRISMA guidelines. Using the PubMed/MEDLINE, Embase, and Web of Science databases, we queried all publications in the English-language literature investigating the effect of oxysterols on

resultsOur search identified 267 unique articles, of which 27 underwent full-text review. Thirteen studies (all preclinical) met our inclusion/exclusion criteria. Of the 13 included studies, 5 employed spinal fusion models, 2 employed critical-sized alveolar defect models, and 6 employed critical-sized calvarial defect models. Based upon SYRCLE criteria, the included studies were found to possess an overall "unclear risk of bias"; 54% of studies reported treatment randomization and 38% reported blinding at any level. Overall, seven unique oxysterols were evaluated: 20(

conclusionPresent preclinical evidence suggests oxysterols significantly augment

Indexed as

BiomaterialBone tissue engineeringCritical-sized defectOrthopaedic surgeryOxysterolSystematic review

Identifiers

PMID32908817
PMCPMC7453739
OpenAlexW3041587669

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.