Evidence map›Paper›PMID 32908737›Full record

ArticleCase reports in nephrology2020

Galactose-Deficient IgA1 Deposits in Clear Cell Renal Cell Carcinoma-Related Henoch-Schönlein Purpura Nephritis.

Yuhong Zhao, Youngki Kim, Milind Junghare, Viral Vakil, Xuesong Su, Faqian Li, Lihong Bu

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Yuhong ZhaoDepartment of Nephrology, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning 110024, China.
Youngki KimDepartment of Pediatrics, Division of Pediatric Nephrology, University of Minnesota, Minneapolis, MN 55455, USA.
Milind JunghareDepartment of Renal Disease and Hypertension, University of Minnesota, Minneapolis, MN 55455, USA.
Viral VakilDepartment of Renal Disease and Hypertension, University of Minnesota, Minneapolis, MN 55455, USA.
Xuesong SuDepartment of Nephrology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.
Faqian LiDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Lihong BuDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.ORCID https://orcid.org/0000-0001-5075-0238
University of Minnesota · USCentral Hospital Affiliated to Shenyang Medical College · CNChina Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies suggest that galactose-deficient IgA1 (Gd-IgA1) plays a role in the pathogenesis of primary IgA nephropathy (IgAN) and Henoch-Schönlein purpura nephritis (HSPN). Furthermore, immunostaining of KM55, an antibody that identifies Gd-IgA1, may be helpful to differentiate primary IgAN and HSPN from secondary causes of glomerular IgA deposition. We report sequential kidney biopsies of a malignancy-associated HSPN, showing intense glomerular mesangial IgA deposition at the initial kidney biopsy and dramatic decrease in disappearance of glomerular deposits after tumor removal. We demonstrate that the glomerular IgA deposition contains Gd-IgA1, detected by immunostaining of KM55, with similar distribution and intensity to IgA. This suggests that renal Gd-IgA1 deposition may play a role in the pathogenesis of malignancy-associated HSPN.

Identifiers

PMID32908737
PMCPMC7463376
OpenAlexW3080401902

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.