ArticleComputational and mathematical methods in medicine2020
A Model for SARS-CoV-2 Infection with Treatment.
Article in Computational and mathematical methods in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- From Legacy to Innovation: Pidotimod's Expanding Therapeutic Horizon.Mediterranean journal of hematology and infectious diseases · 2025Review
- Pidotimod in pediatrics: new evidence and future perspectives.Multidisciplinary respiratory medicine · 2024Article
- Modeling the emergence of viral resistance for SARS-CoV-2 during treatment with an anti-spike monoclonal antibody.PLoS pathogens · 2024Article
- Modeling the emergence of viral resistance for SARS-CoV-2 during treatment with an anti-spike monoclonal antibody.bioRxiv : the preprint server for biology · 2023Article
- Stability of a delayed SARS-CoV-2 reactivation model with logistic growth and adaptive immune response.Physica A · 2023Article
- Mathematical Modeling and Analysis of the Dynamics of RNA Viruses in Presence of Immunity and Treatment: A Case Study of SARS-CoV-2.Vaccines · 2023Article
- Dynamics of a fractional order mathematical model for COVID-19 epidemic transmission.Physica A · 2023Article
- Global Dynamics of SARS-CoV-2 Infection with Antibody Response and the Impact of Impulsive Drug Therapy.Vaccines · 2022Article
- New Therapeutic Options in Mild Moderate COVID-19 Outpatients.Microorganisms · 2022Article
- Timely and effective media coverage's role in the spread of Corona Virus Disease 2019.Mathematical methods in the applied sciences · 2022Article
- Study on the virulence evolution of SARS-CoV-2 and the trend of the epidemics of COVID-19.Mathematical methods in the applied sciences · 2022Article
- Modeling the impact of the vaccine on the COVID-19 epidemic transmission via fractional derivative.European physical journal plus · 2022Article
- Early Prediction Model for Critical Illness of Hospitalized COVID-19 Patients Based on Machine Learning Techniques.Frontiers in public health · 2022Article
- Impact of social media advertisements on the transmission dynamics of COVID-19 pandemic in India.Journal of applied mathematics & computing · 2022Article
- Effect of an antiviral drug control and its variable order fractional network in host COVID-19 kinetics.The European physical journal. Special topics · 2022Article
- Dynamical demeanour of SARS-CoV-2 virus undergoing immune response mechanism in COVID-19 pandemic.The European physical journal. Special topics · 2022Article
- A fractional-order differential equation model of COVID-19 infection of epithelial cells.Chaos, solitons, and fractals · 2021Article
- Current and prospective computational approaches and challenges for developing COVID-19 vaccines.Advanced drug delivery reviews · 2021Review
- A fractional-order SIRD model with time-dependent memory indexes for encompassing the multi-fractional characteristics of the COVID-19.Chaos, solitons, and fractals · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current emergence of coronavirus (SARS-CoV-2) puts the world in threat. The structural research on the receptor recognition by SARS-CoV-2 has identified the key interactions between SARS-CoV-2 spike protein and its host (epithelial cell) receptor, also known as angiotensin-converting enzyme 2 (ACE2). It controls both the cross-species and human-to-human transmissions of SARS-CoV-2. In view of this, we propose and analyze a mathematical model for investigating the effect of CTL responses over the viral mutation to control the viral infection when a postinfection immunostimulant drug (pidotimod) is administered at regular intervals. Dynamics of the system with and without impulses have been analyzed using the basic reproduction number. This study shows that the proper dosing interval and drug dose both are important to eradicate the viral infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.