ArticleNature2020
Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis.
Open access · bronzeAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 2 pooled it
11.9field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
158 citing papers in PubMed, 2 syntheses or guidelines pooled it, 249 citations in OpenAlex.
- Vascularised organoids: Recent advances and applications in cancer research.Clinical and translational medicine · 2025Pooled it
- Recent advancements and future requirements in vascularization of cortical organoids.Frontiers in bioengineering and biotechnology · 2022Pooled it
- Bridging Organ-on-a-Chip and Omics: A Multi-Dimensional Frontier in Biomedical Research.Biotechnology and bioengineering · 2026Review
- TAL1 is indispensable in ETV2-primed human endothelial cell fate determination.Science advances · 2026Article
- Beyond DNA damage: 3D tumor models and the integrin mechanobiology of radioresistance.Journal of experimental & clinical cancer research : CR · 2026Review
- Heart-on-a-chip and vasculature-on-a-chip platforms as models of cardiovascular disease.Nature reviews. Cardiology · 2026Review
- Self-assembly of tumor-related vascularized colorectal tumoroid-on-a-chip for precision medicine drug testing.Cell reports. Medicine · 2026Article
- Neutrophil myeloperoxidase as a functional biomarker for RSV severity: implications for in vitro therapeutic screening.Nature communications · 2026Article
- miR126-mediated alteration of vascular integrity in Rett syndrome.Molecular psychiatry · 2026Article
- Engineering and Integrating Blood Vessel Organoids: a Comprehensive Blueprint for Physiological and Disease Modeling.Stem cell reviews and reports · 2026Review
- Derivation of functional retinal endothelial cells from human pluripotent stem cells for therapeutics and modelling.Nature biomedical engineering · 2026Article
- Organoids: generation strategies, applications, and future challenges.Stem cell research & therapy · 2026Review
- ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models.Advanced healthcare materials · 2026Article
- Modeling early human heart development using an iPSC-based 3D bioprinted model of embryonic heart tube.Nature communications · 2026Article
- Accelerated reprogramming of hiPSCs into functional brain endothelial-like cells using multiplexed CRISPR activation.Scientific reports · 2026Article
- Pre-vascularized enhances therapeutic effects of human bone marrow-derived mesenchymal stem cell sheets in Buccal Mucosa wound.BMC oral health · 2026Article
- Vascularized Cardiac Tissue Engineering: From Advances in Biofabrication to Translational Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- The pre-metastatic niche: mechanisms, heterogeneity, and therapeutic opportunities.Molecular cancer · 2026Review
- Automating Vascular Biology: An End-to-End Automated Workflow for High-Throughput Blood Vessel-on-a-Chip Production and Multi-Site Validation.Advanced healthcare materials · 2026Article
- Lactate-lactylation in tumor angiogenesis and progression: mechanisms, biomarker potential, and therapeutic implications.Biomarker research · 2026Review
98 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 4 institutions in 3 countries.
Brisa PalikuqiDivision of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Duc-Huy T NguyenDivision of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Ge LiDivision of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Ryan SchreinerDivision of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-7457-6606
Alessandro F PellegataStem Cell and Regenerative Medicine Section, DBC Programme, Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID http://orcid.org/0000-0002-5618-4641
Ying LiuDivision of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
David RedmondDivision of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Fuqiang GengDivision of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Yang LinDivision of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-0709-2468
Jesus M Gómez-SalineroDivision of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-9024-2171
Masataka YokoyamaDivision of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Paul ZumboApplied Bioinformatics Core, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Tuo ZhangGenomics Resources Core Facility, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-5396-918X
Balvir KunarDivision of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Mavee WitherspoonSandra and Edward Meyer Cancer Center, Weill Cornell Graduate School of Medical Sciences, Departments of Biochemistry and Medicine, Weill Cornell Medicine, New York, NY, USA.
Teng HanSandra and Edward Meyer Cancer Center, Weill Cornell Graduate School of Medical Sciences, Departments of Biochemistry and Medicine, Weill Cornell Medicine, New York, NY, USA.
Alfonso M TedeschiStem Cell and Regenerative Medicine Section, DBC Programme, Great Ormond Street Institute of Child Health, University College London, London, UK.
Federico ScottoniStem Cell and Regenerative Medicine Section, DBC Programme, Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID http://orcid.org/0000-0001-6796-7919
Steven M LipkinSandra and Edward Meyer Cancer Center, Weill Cornell Graduate School of Medical Sciences, Departments of Biochemistry and Medicine, Weill Cornell Medicine, New York, NY, USA.
Lukas DowSandra and Edward Meyer Cancer Center, Weill Cornell Graduate School of Medical Sciences, Departments of Biochemistry and Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-7048-1418
Olivier ElementoCaryl and Israel Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
Jenny Z XiangGenomics Resources Core Facility, Weill Cornell Medicine, New York, NY, USA.
Koji ShidoDivision of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-6303-3238
Jason R SpenceDepartment of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7869-3992
Qiao J ZhouDivision of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Robert E SchwartzDivision of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Paolo De CoppiStem Cell and Regenerative Medicine Section, DBC Programme, Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID http://orcid.org/0000-0002-1659-0207
Sina Y RabbanyDivision of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Shahin RafiiDivision of Regenerative Medicine, Ansary Stem Cell Institute, Department of Medicine, Weill Cornell Medicine, New York, NY, USA. srafii@med.cornell.edu.
Cornell University · USGreat Ormond Street Hospital · GBHofstra University · USUniversity of Michigan · US
Funding
Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2MPilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RANDY J SEELEY · 2010 to 2026
$20.3MAdaptable tissue-specific endothelial cells for organ regenerationR35HL150809 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Shahin Rafii · 2020 to 2026
$7.1MGenetic Viral and Host Adaptations to Breach Species Barriers of HCVR01AI107301 · NIAID · PRINCETON UNIVERSITY · PI Thomas Pietschmann, Alexander Ploss · 2013 to 2026
$6.0MA Gata456 Pipeline of DiscoveryR35HL135778 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI EVANS, TODD R · 2017 to 2023
$5.7MSupplement to a Hox-Wnt-Sox signaling axis regulates lung development, patterning and branchingR01HL119215 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPENCE, JASON · 2013 to 2021
$4.2MEndothelial cell transplantation for multi-organ repair to counter radiation injuryU01AI138329 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI KIEM, HANS-PETER, RAFII, SHAHIN · 2018 to 2022
$3.3MEvaluation of Pluripotent Stem Cell-Derived Blood Cells in Nonhuman Primate ModelR01HL115128 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KIEM, HANS-PETER, RAFII, SHAHIN · 2013 to 2016
$3.3MNiche signals in HSC genesisRC2DK114777 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BERNSTEIN, IRWIN D, RAFII, SHAHIN · 2017 to 2021
$3.3MDeciphering molecular determinants of vascular heterogeneity for organ repairR01HL128158 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI RAFII, SHAHIN · 2014 to 2018
$3.1MOptimization of the engineered 3D hepatic microenvironment enhances pluripotent stem cell derived hepatocyteR01DK121072 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI SCHWARTZ, ROBERT E · 2020 to 2024
$2.6MThe identification and validation of mechanisms and biomarkers for relapse in diffuse large B-cell lymphoma (Administrative Supplement)R01CA194547 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI ELEMENTO, OLIVIER, TAM, WAYNE · 2015 to 2019
$2.6MMedical Research Council MR/N028414/1NCATS NIH HHS UL1 TR002384NCI NIH HHS R01 CA194547NCI NIH HHS R01 CA234614NHLBI NIH HHS R01 HL115128NHLBI NIH HHS R01 HL119215NHLBI NIH HHS R01 HL119872NHLBI NIH HHS R01 HL128158NHLBI NIH HHS R01 HL139056NHLBI NIH HHS R35 HL150809NIAAA NIH HHS R01 AA027327NIAID NIH HHS R01 AI107301NIAID NIH HHS R21 AI117213NIAID NIH HHS U01 AI138329NIA NIH HHS R01 AG056298NIDDK NIH HHS DP3 DK111907NIDDK NIH HHS K08 DK101754NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK095039NIDDK NIH HHS R01 DK106253NIDDK NIH HHS R01 DK121072NIDDK NIH HHS R03 DK117252NIDDK NIH HHS RC2 DK114777NIDDK NIH HHS UC4 DK116280NIH HHS 1R21AI117213NIMH NIH HHS F30 MH115616
Abstract
Endothelial cells adopt tissue-specific characteristics to instruct organ development and regeneration
Indexed as
CarcinogenesisHemodynamicsOrganogenesisBlood VesselsCell Culture TechniquesChromatinEndothelial CellsEpigenesis, GeneticEpigenomicsHumansHuman Umbilical Vein Endothelial CellsIn Vitro TechniquesIslets of LangerhansModels, BiologicalNeoplasmsOrganoidsChromatinETV2 protein, humanTranscription Factors
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.