Evidence map›Paper›PMID 32907992›Full record

ArticleJournal of clinical microbiology2020

Characterization of Genomic Variants Associated with Resistance to Bedaquiline and Delamanid in Naive Mycobacterium tuberculosis Clinical Strains.

S Battaglia, A Spitaleri, A M Cabibbe, C J Meehan, C Utpatel, N Ismail, S Tahseen, A Skrahina, N Alikhanova, S M Mostofa Kamal and 7 more

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 11 institutions in 10 countries.

S BattagliaEmerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0003-3854-4110
A SpitaleriEmerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0003-3012-3557
A M CabibbeEmerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID 0000-0001-9727-6465
C J MeehanSchool of Chemistry and Biosciences, University of Bradford, Bradford, United Kingdom.ORCID 0000-0003-0724-8343
C UtpatelMolecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.
N IsmailCentre for Tuberculosis, National Institute for Communicable Diseases, National Health Laboratory Services, Johannesburg, South Africa.ORCID 0000-0001-7696-3776
S TahseenNational TB Reference Laboratory, National Tuberculosis Control Program, Islamabad, Pakistan.
A SkrahinaRepublic Research and Practical Centre for Pulmonology and Tuberculosis, Minsk, Belarus.
N AlikhanovaScientific Research Institute of Lung Diseases, Ministry of Health, Baku, Azerbaijan.
S M Mostofa KamalNational TB Reference Laboratory, National Institute of Diseases of the Chest and Hospital, Dhaka, Bangladesh.
A BarbovaCentral Reference Laboratory on Tuberculosis Microbiological Diagnostics, Ministry of Health, Kiev, Ukraine.
S NiemannMolecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.
R GroenheitUnit for Laboratory Surveillance of Bacterial Pathogens, Public Health Agency of Sweden, Solna, Sweden.
A S DeanGlobal TB Programme, World Health Organization, Geneva, Switzerland.
M ZignolGlobal TB Programme, World Health Organization, Geneva, Switzerland.
L RigoutsUnit of Mycobacteriology, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
D M CirilloEmerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy cirillo.daniela@hsr.it.ORCID 0000-0001-6415-1535
Vita-Salute San Raffaele University · ITWorld Health Organization · CHGerman Center for Infection Research · DEMinistry of Healthcare · AZNational Health Laboratory Service · ZANational Institute of Cardiovascular Diseases · BDPublic Health Agency of Sweden · SERepublican Scientific and Practical Centre of Pulmonology and Tuberculosis · BYResearch Center Borstel - Leibniz Lung Center · DEUniversity of Antwerp · BEUniversity of Bradford · GB

Funding

World Health Organization 001
6 · The paper itself

Abstract

The role of mutations in genes associated with phenotypic resistance to bedaquiline (BDQ) and delamanid (DLM) in

Indexed as

Mycobacterium tuberculosisTuberculosis, Multidrug-ResistantAntitubercular AgentsDiarylquinolinesGenomicsHumansMicrobial Sensitivity TestsNitroimidazolesOxazolesAntitubercular AgentsbedaquilineDiarylquinolinesNitroimidazolesOPC-67683OxazolesbedaquilinedelamanidMycobacterium tuberculosisresistance to new drugswhole-genome sequencing

Identifiers

PMID32907992
PMCPMC7587096
OpenAlexW3084162952

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.