ArticleJournal of virology2020
Telomere and ATM Dynamics in CD4 T-Cell Depletion in Active and Virus-Suppressed HIV Infections.
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Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
What it found
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- HIV associated immune aging among people living with HIV: implications for long-term antiretroviral therapy and potential HIV cure interventions in sub-Saharan Africa.Frontiers in immunology · 2026Review
- Inhibition of protein kinase R suppresses HIV replication and integration in CD4 T cells.Journal of virus eradication · 2025Article
- miR-23a-mediated TRF2 repression in CD4 T cells from PLWH.Molecular immunology · 2025Article
- Regulation of cellular senescence in tumor progression and therapeutic targeting: mechanisms and pathways.Molecular cancer · 2025Review
- The Complex Interactions Between HIV-1 and Human Host Cell Genome: From Molecular Mechanisms to Clinical Practice.International journal of molecular sciences · 2025Review
- Identification and validation of biomarkers related to ferroptosis in idiopathic pulmonary fibrosis.Scientific reports · 2025Article
- Circulating GDF-15: a biomarker for metabolic dysregulation and aging in people living with HIV.Frontiers in aging · 2024Article
- ROS-Induced Mitochondrial Dysfunction in CD4 T Cells from ART-Controlled People Living with HIV.Viruses · 2023Article
- Article
- TRF2 inhibition rather than telomerase disruption drives CD4T cell dysfunction during chronic viral infection.Journal of cell science · 2022Article
- Mitochondrial topoisomerase 1 inhibition induces topological DNA damage and T cell dysfunction in patients with chronic viral infection.Frontiers in cellular and infection microbiology · 2022Article
- Selective oxidative stress induces dual damage to telomeres and mitochondria in human T cells.Aging cell · 2021Article
- Review
- Mitochondrial Functions Are Compromised in CD4 T Cells From ART-Controlled PLHIV.Frontiers in immunology · 2021Article
- Long Non-coding RNA GAS5 Regulates T Cell Functions via miR21-Mediated Signaling in People Living With HIV.Frontiers in immunology · 2021Article
- A Matter of Life or Death: Productively Infected and Bystander CD4 T Cells in Early HIV Infection.Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
21 authors at 2 institutions in 2 countries.
Sushant Khanal *Center of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Qiyuan Tang *The Third People's Hospital, Shenzhen, China.
Dechao CaoCenter of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Juan ZhaoCenter of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Lam Nhat NguyenCenter of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Oluwayomi Samson OyedejiCenter of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Xindi DangCenter of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Lam Ngoc Thao NguyenCenter of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Madison SchankCenter of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Bal Krishna Chand ThakuriCenter of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Chinyere OgbuCenter of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Zheng D MorrisonCenter of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Xiao Y WuCenter of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Zheng ZhangThe Third People's Hospital, Shenzhen, China.
Qing HeThe Third People's Hospital, Shenzhen, China.
Mohamed El GazzarCenter of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Zhengke LiCenter of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Shunbin NingCenter of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Ling WangCenter of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Jonathan P MoormanCenter of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA.
Zhi Q YaoCenter of Excellence in Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, USA yao@etsu.edu.ORCID 0000-0002-1333-1007
East Tennessee State University · USShenzhen Third People’s Hospital · CN
Funding
miRNA-mediated premature T cell aging in vaccine failure during viral infectionR01AI114748 · NIAID · EAST TENNESSEE STATE UNIVERSITY · PI YAO, ZHI Q. · 2015 to 2019
$1.9MTelomere loss and T cell aging in HBV vaccine response in HIV-infected individualR21AI138598 · NIAID · EAST TENNESSEE STATE UNIVERSITY · PI YAO, ZHI Q. · 2018 to 2019
$407kBLRD VA I01 BX002670BLRD VA I01 BX004281NIAID NIH HHS R01 AI114748NIAID NIH HHS R21 AI138598
Abstract
CD4 T-cell depletion is a hallmark of HIV/AIDS, but the underlying mechanism is still unclear. We have recently shown that ataxia-telangiectasia-mutated (ATM) deficiency in CD4 T cells accelerates DNA damage, telomere erosion, and cell apoptosis in HIV-infected individuals on antiretroviral therapy (ART). Whether these alterations in ART-treated HIV subjects occur
Indexed as
ApoptosisAtaxia TelangiectasiaAtaxia Telangiectasia Mutated ProteinsCD4-Positive T-LymphocytesCell LineCellular SenescenceDNA DamageHEK293 CellsHIV-1HIV InfectionsHumansTelomereVirus ReplicationAtaxia Telangiectasia Mutated ProteinsapoptosisATMATM kinasesDNA damage responseHIVT-cell homeostasistelomere
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.