Evidence map›Paper›PMID 32907945›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Structure-function studies of Rgg binding to pheromones and target promoters reveal a model of transcription factor interplay.

Glenn C Capodagli, Kaitlyn M Tylor, Jason T Kaelber, Vasileios I Petrou, Michael J Federle, Matthew B Neiditch

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

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  6. The MutRS quorum-sensing system controls lantibiotic mutacin production in the human pathogenProceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Glenn C CapodagliDepartment of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers Biomedical Health Sciences, Newark, NJ 07103.ORCID 0000-0002-0227-4529
Kaitlyn M TylorDepartment of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60607.ORCID 0000-0002-3117-6338
Jason T KaelberRutgers New Jersey Cryo-Electron Microscopy & Tomography Core Facility, Rutgers University, Piscataway, NJ 08854.ORCID 0000-0001-9426-1030
Vasileios I PetrouDepartment of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers Biomedical Health Sciences, Newark, NJ 07103; vasileios.petrou@rutgers.edu mfederle@uic.edu matthew.neiditch@rutgers.edu.ORCID 0000-0002-3194-9863
Michael J FederleDepartment of Pharamaceutical Sciences, Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL 60607 vasileios.petrou@rutgers.edu mfederle@uic.edu matthew.neiditch@rutgers.edu.ORCID 0000-0002-4554-543X
Matthew B NeiditchDepartment of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers Biomedical Health Sciences, Newark, NJ 07103; vasileios.petrou@rutgers.edu mfederle@uic.edu matthew.neiditch@rutgers.edu.ORCID 0000-0002-7039-4469
Rutgers, The State University of New Jersey · USUniversity of Illinois Chicago · US

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
Mechanistic Dissection of Pheromone-Dependent Regulation of Group A StreptococcalR01AI091779 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FEDERLE, MICHAEL J · 2011 to 2021
$3.9M
Molecular Mechanisms of Rgg Receptor Regulation by Pheromones and InhibitorsR01AI125452 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI FEDERLE, MICHAEL J, NEIDITCH, MATTHEW B · 2016 to 2019
$1.9M
STRUCTURAL BASIS OF AMINORABINOSE BIOSYNTHESIS LINKED TO POLYMYXIN RESISTANCER00GM123228 · NIGMS · RBHS-NEW JERSEY MEDICAL SCHOOL · PI PETROU, VASILEIOS I · 2019 to 2021
$747k
NIAID NIH HHS R01 AI091779NIAID NIH HHS R01 AI125452NIGMS NIH HHS P41 GM103393NIGMS NIH HHS R00 GM123228
6 · The paper itself

Abstract

Regulator gene of glucosyltransferase (Rgg) family proteins, such as Rgg2 and Rgg3, have emerged as primary quorum-sensing regulated transcription factors in

Indexed as

Bacterial ProteinsCryoelectron MicroscopyGene Expression Regulation, BacterialPheromonesStreptococcusStreptococcus thermophilusTrans-ActivatorsBacterial ProteinsPheromonesrgg protein, StreptococcusTrans-Activatorscryo-EMpeptide pheromonesquorum sensingRRNPP proteinsX-ray crystallography

Identifiers

PMID32907945
PMCPMC7533842
OpenAlexW3083778496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.