ArticleThe European respiratory journal2020
Elevated D-dimers and lack of anticoagulation predict PE in severe COVID-19 patients.
Article in The European respiratory journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 10 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Heart failure during the COVID-19 pandemic: clinical, diagnostic, management, and organizational dilemmas.ESC heart failure · 2022Pooled it
- Pulmonary embolism in patients with COVID-19 and value of D-dimer assessment: a meta-analysis.European radiology · 2021Pooled it
- Guideline
- Risk factors for pulmonary embolism in patients with COVID-19: a systemic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Pooled it
- A systematic review and meta-analysis of incidence, prognosis, and laboratory indicators of venous thromboembolism in hospitalized patients with coronavirus disease 2019.Journal of vascular surgery. Venous and lymphatic disorders · 2021Pooled it
- Mortality and risk factors associated with pulmonary embolism in coronavirus disease 2019 patients: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Venous thromboembolism in COVID-19: A systematic review and meta-analysis.Vascular medicine (London, England) · 2021Pooled it
- Management of hospitalised adults with coronavirus disease 2019 (COVID-19): a European Respiratory Society living guideline.The European respiratory journal · 2021Guideline
- COVID-19 and Cardiomyopathy: A Systematic Review.Frontiers in cardiovascular medicine · 2021Pooled it
- Diagnostic Value of D-Dimer in COVID-19: A Meta-Analysis and Meta-Regression.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisPooled it
- Thrombophilic Changes and Hematological Complications in Asthmatic Patients with COVID-19: A Systematic Review.Diseases (Basel, Switzerland) · 2025Review
- Predictive modelling and identification of critical variables of mortality risk in COVID-19 patients.Scientific reports · 2025Article
- Utility of D-dimer in predicting pulmonary embolism in patients with COVID-19 presenting to the emergency department.Journal of the American College of Emergency Physicians open · 2024Article
- A Nomogram Model Containing Genetic Polymorphisms to Predict Risk of Pulmonary Embolism in Pregnant Women.International journal of women's health · 2024Article
- Menstrual changes after the thrombo-prophylaxis or anticoagulants used during the COVID-19 infection.Przeglad menopauzalny = Menopause review · 2023Article
- Simple demographic, laboratory and chest radiograph variables can identify COVID-19 patients with pulmonary thromboembolism: a retrospective multicentre United Kingdom study.The British journal of radiology · 2023Article
- An optimized D-dimer cut-off value to predict pulmonary thromboembolism in COVID-19 patients.Journal of thoracic disease · 2023Article
- Multivariable Risk Modelling and Survival Analysis with Machine Learning in SARS-CoV-2 Infection.Journal of clinical medicine · 2023Article
- Improved Survival of IPF patients Treated With Antifibrotic Drugs Compared With Untreated Patients.Lung · 2023Observational
- Strategies to safely rule out pulmonary embolism in COVID-19 outpatients: a multicenter retrospective study.European radiology · 2023Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
17 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronavirus disease 2019 (COVID-19) may predispose to venous thromboembolism. We determined factors independently associated with computed tomography pulmonary angiography (CTPA)-confirmed pulmonary embolism (PE) in hospitalised severe COVID-19 patients.
methodsAmong all (n=349) patients hospitalised for COVID-19 in a university hospital in a French region with a high rate of COVID-19, we analysed patients who underwent CTPA for clinical signs of severe disease (oxygen saturation measured by pulse oximetry ≤93% or breathing rate ≥30 breaths·min
results162 (46.4%) patients underwent CTPA (mean±sd age 65.6±13.0 years; 67.3% male (95% CI 59.5-75.5%). PE was diagnosed in 44 (27.2%) patients. Most PEs were segmental and the rate of PE-related right ventricular dysfunction was 15.9%. By multivariable analysis, the only two significant predictors of CTPA-confirmed PE were D-dimer level and the lack of any anticoagulant therapy (OR 4.0 (95% CI 2.4-6.7) per additional quartile and OR 4.5 (95% CI 1.1-7.4), respectively). Receiver operating characteristic curve analysis identified a D-dimer cut-off value of 2590 ng·mL
conclusionElevated D-dimers (>2590 ng·mL
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.