ArticleParasites & vectors2020
The threat of reduced efficacy of anthelmintics against gastrointestinal nematodes in sheep from an area considered anthelmintic resistance-free.
Article in Parasites & vectors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Differential Effect of Ivermectin on Intestinal Helminths in Multimmate Mouse (Mastomys natalensis).Veterinary medicine and science · 2026Article
- Integrated epidemiology and multi-assay evidence of anthelmintic resistance in ovine gastrointestinal nematodes of Northern India.Scientific reports · 2026Article
- Preclinical evaluation of Senna alata leaf extract against Hymenolepis diminuta: a promising natural anthelmintic solution.BMC complementary medicine and therapies · 2026Article
- The use of pumpkin seeds as an alternative anthelmintic to reduce parasite burden in naturally infected lambs.Translational animal science · 2026Article
- Anthelmintic control failure and associated risk factors reported by farmers in communal sheep farming, Oliver Tambo District, Eastern Cape, South Africa.Veterinary record open · 2025Article
- Epidemiological insights into bovine helminthiasis in Upper Egypt: Prevalence, risk factors, and pathological findings.Veterinarni medicina · 2025Article
- Parasite diversity in grey wolves (International journal for parasitology. Parasites and wildlife · 2025Article
- Surveillance of anthelmintic treatments on ruminant farms to detect resistance in a low-prevalence area.BMC veterinary research · 2025Article
- Escherichia coli is implicated in the development and manifestation of host susceptibility to the roundworm Trichostrongylus colubriformis infections in sheep.Veterinary research · 2025Article
- Anthelmintic activity of winter savory (Satureja montana L.) essential oil against gastrointestinal nematodes of sheep.BMC veterinary research · 2025Article
- Prediction and Prioritisation of Novel Anthelmintic Candidates from Public Databases Using Deep Learning and Available Bioactivity Data Sets.International journal of molecular sciences · 2025Article
- Review
- Treatment ineffectiveness towards Haemonchus contortus is highly prevalent in sheep and goat farms of North-Eastern Italy.BMC veterinary research · 2024Article
- Prevalence of Helminths in Small Ruminant Farms and Evaluation of Control Practices Used to Counter Anthelmintic Resistance in Southern Italy.Pathogens (Basel, Switzerland) · 2024Article
- Article
- Epidemiology and field efficacy of anthelmintic drugs associated with gastrointestinal nematodes of sheep in Nejo district, Oromia, Ethiopia.Scientific reports · 2024Article
- Effect of pomegranate (Frontiers in veterinary science · 2024Article
- Anthelmintic resistance in soil-transmitted helminths: One-Health considerations.Parasitology research · 2023Review
- Gastrointestinal Parasite Infections and Environmental Sustainability of the Ovine Sector:Pathogens (Basel, Switzerland) · 2023Article
- Chemical Profile of Essential Oils of Selected Lamiaceae Plants and In Vitro Activity for Varroosis Control in HoneybeesVeterinary sciences · 2023Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe worldwide increased difficulty to combat gastrointestinal nematode (GIN) infection in sheep, due to progressing anthelmintic resistance (AR), calls for an enhanced and standardized implementation of early detection of AR. This study provides a snapshot of the current AR status against benzimidazoles and macrocyclic lactones in southern Italy, generated with standardized techniques.
methodsOn 10 sheep farms, the efficacy of albendazole (ALB) and either eprinomectin (EPR) or ivermectin (IVM) was evaluated based on the faecal egg count reduction test (FECRT) performed with the Mini-FLOTAC. For each tested drug, 40 sheep were rectally sampled at D0 and sampled again 14 days after the treatment (D14). The FECRT was calculated from individual samples and pooled samples which consist of 5 individual samples. Efficacy was classified as 'reduced, 'suspected' and 'normal'. Coprocultures were set for D0 and D14 faecal samples of each group. From farms with FECR < 95%, an in vitro egg hatch test (EHT) and a follow-up FECRT using fenbendazole (FBZ) were conducted.
resultsBased on the FECR, high efficacy (from 95.7% to 100%) was observed for ALB and IVM in eight farms (Farms 3-10). On Farm 1 and Farm 2, the efficacy for the macrocyclic lactones was classified as 'normal', but 'reduced' efficacy was observed for ALB on Farm 1 (FECR = 75%) and 'suspected' efficacy on Farm 2 (FECR = 93.3%) with the predominant GIN genus Trichostrongylus followed by Haemonchus at D14. The FEC results of pooled samples strongly correlated with those of individual samples, for FEC at D0 (r
conclusionsIn regions like southern Italy, where the negative impacts from AR have played a minor role, efficient monitoring of AR is important in order to evaluate potential risks and being able to promptly respond with countermeasures.
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