Evidence map›Paper›PMID 32907533›Full record

ArticleBMC infectious diseases2020

Prognostic role of time to positivity of blood culture in children with Pseudomonas aeruginosa bacteremia.

Huiting Xu, Jie Cheng, Qinghong Yu, Qingyuan Li, Qian Yi, Siying Luo, Yuanyuan Li, Guangli Zhang, Xiaoyin Tian, Dapeng Cheng and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Huiting XuKey Laboratory of Pediatrics in Chongqing, Chongqing, 400014, China.
Jie ChengKey Laboratory of Pediatrics in Chongqing, Chongqing, 400014, China.
Qinghong YuKey Laboratory of Pediatrics in Chongqing, Chongqing, 400014, China.
Qingyuan LiKey Laboratory of Pediatrics in Chongqing, Chongqing, 400014, China.
Qian YiKey Laboratory of Pediatrics in Chongqing, Chongqing, 400014, China.
Siying LuoKey Laboratory of Pediatrics in Chongqing, Chongqing, 400014, China.
Yuanyuan LiDepartment of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing, 401122, China.
Guangli ZhangDepartment of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing, 401122, China.
Xiaoyin TianDepartment of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing, 401122, China.
Dapeng ChengDepartment of Clinical Laboratory center, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China.
Zhengxiu LuoDepartment of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing, 401122, China. luozhengxiu816@hospital.cqmu.edu.cn.ORCID http://orcid.org/0000-0003-3029-9624
China International Science and Technology Cooperation · CNChildren's Hospital of Chongqing Medical University · CN

Funding

national key clinical specialty 2011-873
6 · The paper itself

Abstract

backgroundPseudomonas aeruginosa (P. aeruginosa) is a major Gram-negative pathogen, which has been reported to result in high mortality. We aim to investigate the prognostic value and optimum cut-off point of time-to-positivity (TTP) of blood culture in children with P. aeruginosa bacteremia.

methodsFrom August 2014 to November 2018, we enrolled the inpatients with P. aeruginosa bacteremia in a 1500-bed tertiary teaching hospital in Chongqing, China retrospectively. Receiver operating characteristic (ROC) analysis was used to determine the optimum cut-off point of TTP, and logistic regression were employed to explore the risk factors for in-hospital mortality and septic shock.

resultsTotally, 52 children with P. aeruginosa bacteremia were enrolled. The standard cut-off point of TTP was18 h. Early TTP (≤18 h) group patients had remarkably higher in-hospital mortality (42.9% vs 9.7%, P = 0.014), higher incidence of septic shock (52.4% vs12.9%, P = 0.06), higher Pitt bacteremia scores [3.00 (1.00-5.00) vs 1.00 (1.00-4.00), P = 0.046] and more intensive care unit admission (61.9% vs 22.6%, P = 0.008) when compared with late TTP (> 18 h) groups. Multivariate analysis indicated TTP ≤18 h, Pitt bacteremia scores ≥4 were the independent risk factors for in-hospital mortality (OR 5.88, 95%CI 1.21-21.96, P = 0.035; OR 4.95, 95%CI 1.26-27.50, P = 0.024; respectively). The independent risk factors for septic shock were as follows: TTP ≤18 h, Pitt bacteremia scores ≥4 and hypoalbuminemia (OR 6.30, 95%CI 1.18-33.77, P = 0.032; OR 8.15, 95%CI 1.15-42.43, P = 0.014; OR 6.46, 95% CI 1.19-33.19 P = 0.031; respectively).

conclusionsEarly TTP (≤18 hours) appeared to be associated with worse outcomes for P. aeruginosa bacteremia children.

Indexed as

Blood CultureBacteremiaChildChild, PreschoolChinaFemaleHospitalizationHospital MortalityHumansInfantIntensive Care UnitsLogistic ModelsMalePrognosisPseudomonas aeruginosaPseudomonas InfectionsBacteremiaChildrenOutcomesPseudomonas aeruginosaTime to positivity

Identifiers

PMID32907533
PMCPMC7488235
OpenAlexW3084013310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.