Evidence map›Paper›PMID 32906728›Full record

ArticlePolymers2020

Core-Shell Eudragit S100 Nanofibers Prepared via Triaxial Electrospinning to Provide a Colon-Targeted Extended Drug Release.

Yanfei Ding, Cheng Dou, Shuyue Chang, Zhengming Xie, Deng-Guang Yu, Yanan Liu, Jun Shao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 118 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yanfei DingSchool of Materials Science & Engineering, University of Shanghai for Science & Technology, 516 Jungong Road, Shanghai 200093, China.
Cheng DouSchool of Materials Science & Engineering, University of Shanghai for Science & Technology, 516 Jungong Road, Shanghai 200093, China.
Shuyue ChangSchool of Materials Science & Engineering, University of Shanghai for Science & Technology, 516 Jungong Road, Shanghai 200093, China.
Zhengming XieSchool of Materials Science & Engineering, University of Shanghai for Science & Technology, 516 Jungong Road, Shanghai 200093, China.
Deng-Guang YuSchool of Materials Science & Engineering, University of Shanghai for Science & Technology, 516 Jungong Road, Shanghai 200093, China.ORCID 0000-0001-7825-4498
Yanan LiuSchool of Materials Science & Engineering, University of Shanghai for Science & Technology, 516 Jungong Road, Shanghai 200093, China.
Jun ShaoShanghai Institute of Technical Physics, Chinese Academy of Sciences, 500 Yutian Road, Shanghai 200083, China.
University of Shanghai for Science and Technology · CNShanghai Institute of Technical Physics · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, a new modified triaxial electrospinning is implemented to generate an Eudragit S100 (ES100)-based core-shell structural nanofiber (CSF), which is loaded with aspirin. The CSFs have a straight line morphology with a smooth surface, an estimated average diameter of 740 ± 110 nm, and a clear core-shell structure with a shell thickness of 65 nm, as disclosed by the scanning electron microscopy and transmission electron microscopy results. Compared to the monolithic composite nanofibers (MCFs) produced using traditional blended single-fluid electrospinning, aspirin presented in both of them amorously owing to their good compatibility. The CSFs showed considerable advantages over the MCFs in providing the desired drug-controlled-release profiles, although both of them released the drug in an erosion mechanism. The former furnished a longer time period of time-delayed-release and a smaller portion released during the first two-hour acid condition for protecting the stomach membranes, and also showed a longer time period of aspirin-extended-release for avoiding possible drug overdose. The present protocols provide a polymer-based process-nanostructure-performance relationship to optimize the reasonable delivery of aspirin.

Indexed as

aspirincolon-targetedcore–shell structureextended-releasetriaxial electrospinning

Identifiers

PMID32906728
PMCPMC7565919
OpenAlexW3083527999

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.