Evidence map›Paper›PMID 32906688›Full record

ArticleCancers2020

Combination Treatment with GSK126 and Pomalidomide Induces B-Cell Differentiation in

Sungryul Park, Seung-Hyun Jo, Jong-Hwan Kim, Seon-Young Kim, Jae Du Ha, Jong Yeon Hwang, Myeong Youl Lee, Jong Soon Kang, Tae-Su Han, Sung Goo Park and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Sungryul ParkDisease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.
Seung-Hyun JoDisease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.ORCID 0000-0002-7969-4601
Jong-Hwan KimPersonalized Genomic Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea.
Seon-Young KimKRIBB School of Bioscience, Korea University of Science and Technology, Daejeon 34113, Korea.
Jae Du HaDrug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Korea.
Jong Yeon HwangDrug Discovery Division, Korea Research Institute of Chemical Technology, Daejeon 305-606, Korea.
Myeong Youl LeeLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.
Jong Soon KangLaboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.
Tae-Su HanBiotherapeutics Translational Research Center, Division of Biomedical Science, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.
Sung Goo ParkDisease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.
Sunhong KimDrug Discovery Center, LG Chem Ltd., Seoul 07796, Korea.
Byoung Chul ParkDisease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.
Jeong-Hoon KimDisease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Korea.ORCID 0000-0001-6338-7175
Korea Research Institute of Bioscience and Biotechnology · KRLG (South Korea) · KRKorea Research Institute of Chemical Technology · KR

Funding

KRIBB KRIBB initiative programNational Research Council of Science and Technology CAP-15-11-KRICTNational Research Foundation NRF-2019M3E5D4069882
6 · The paper itself

Abstract

Enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), the catalytic subunit of polycomb repressive complex 2 (PRC2), regulates genes involved in cell lineage and differentiation through methylating lysine 27 on histone H3 (H3K27me3). Recurrent gain-of-function mutations of

Indexed as

combination therapyDLBCLEZH2GSK126IMiDpomalidomidePRC2synergistic effect

Identifiers

PMID32906688
PMCPMC7565736
OpenAlexW3083013039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.