ArticleViruses2020
Identification of the Immediate-Early Genes of Cyprinid Herpesvirus 2.
Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Environmental-Nitrite-Enhanced Cyprinid Herpesvirus 2 Infection in Crucian Carp.Veterinary sciences · 2026Article
- Analysis of MHC class II-bound CyHV-2 peptides inJournal of virology · 2026Article
- Attenuation mechanisms of the P7-P8 live-attenuatedThe Journal of general virology · 2026Article
- Article
- Proteogenomic analysis of Cyprinid herpesvirus 2 using high-resolution mass spectrometry.Journal of virology · 2025Article
- Genomic and molecular characterization of a cyprinid herpesvirus 2 YC-01 strain isolated from gibel carp.Heliyon · 2024Article
- Alterations of Plasma Biochemical and Immunological Parameters and Spatiotemporal Expression of TLR2 and TLR9 in Gibel Carp (Pathogens (Basel, Switzerland) · 2023Article
- Screening and identification of cyprinid herpesvirus 2 (CyHV-2) ORF55-interacting proteins by phage display.Virology journal · 2023Article
- Advances in Viral Aquatic Animal Disease Knowledge: The Molecular Methods' Contribution.Biology · 2023Review
- The identification of viral ribonucleotide reductase encoded by ORF23 and ORF141 genes and effect on CyHV-2 replication.Frontiers in microbiology · 2023Article
- Article
- Quick detection ofFrontiers in cellular and infection microbiology · 2022Article
- Susceptibility of Goldfish to Cyprinid Herpesvirus 2 (CyHV-2) SH01 Isolated from Cultured Crucian Carp.Viruses · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyprinid herpesvirus 2 (CyHV-2), which infects goldfish and crucian carp causing high mortality, is an emerging viral pathogen worldwide. The genome of CyHV-2 is large and comprises double-stranded DNA, including several genes similar to cyprinid herpesvirus 1, ictalurid herpesvirus-1, cyprinid herpesvirus 3, and ranid herpesvirus-1. Genes of DNA viruses are expressed in three temporal phases: immediate-early (IE), early (E), and late (L) genes. Viral IE genes initiate transcription as soon as the virus enters the host, without viral DNA replication. IE gene products enable the efficient expression of E and L genes or regulate the host to initiate virus replication. In the present study, five IE genes of CyHV-2 were identified, including open reading frame (ORF)54, ORF121, ORF141, ORF147, and ORF155. Time course analysis and reverse transcription polymerase chain reaction confirmed five IE genes, thirty-four E genes, and thirty-nine L genes. In addition, all 150 ORFs identified in the CyHV-2 genome are transcribed, and are expressed in chronological order, similar to other herpesviruses. This study is the first to identify the IE genes of CyHV-2, which will provide more information for viral molecular characterization.
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