ArticleNature2020
SLC25A51 is a mammalian mitochondrial NAD
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In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 206 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
206citing papers in PubMed, 1 pooled it
13.6field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
206 citing papers in PubMed, 1 synthesis or guideline pooled it, 289 citations in OpenAlex.
- Protective Effects of Nicotinamide Adenine Dinucleotide and Related Precursors in Alzheimer's Disease: A Systematic Review of Preclinical Studies.Journal of molecular neuroscience : MN · 2021Pooled it
- Remodeling of mitochondrial dynamics by metabolic pathways couples to oncogenic growth inScience advances · 2026Article
- Nicotinamide mononucleotide potentiates the anti-tumor efficacy of CAR-NK cell therapy targeting MSLN in ovarian cancer.Cancer gene therapy · 2026Article
- Noninvasive methods to monitor dynamic single-cell events.Trends in cell biology · 2026Review
- Nicotinamide Mononucleotide Adenylyltransferase 1 and NADMetabolites · 2026Review
- Pyrroloquinoline Quinone and NADPharmaceuticals (Basel, Switzerland) · 2026Review
- SelO-mediated nicotinamide adenine dinucleotide hydrolysis and its implications for metabolic therapies.Clinical and translational medicine · 2026Article
- SelO-mediated NADMolecular biomedicine · 2026Article
- SLC25A51 and mitochondrial NAD⁺ transport in acute myeloid leukemia: mechanisms, therapeutic potential, and translational perspectives.Human cell · 2026Review
- NAD Metabolism in Acute Myeloid Leukaemia: Biological Rationale and Therapeutic Opportunities.Nutrients · 2026Review
- Impact of mitochondrial reductive stress due to respiratory chain limitation on cancer via posttranslational modifications.Redox biology · 2026Review
- Peroxisome Carrier SLC25A17: Potential Biomarker for Peroxisome Dysfunction and Human Disease.International journal of molecular sciences · 2026Review
- Mitochondrial Dynamics and SLC25 Transporters in Neurodegeneration: From Mechanisms to Therapeutic Opportunities.Biomolecules · 2026Review
- Nutrition Information Briefs - Niacin.Advances in nutrition (Bethesda, Md.) · 2026Article
- Review
- The Mitochondrial NAD Transporter SLC25A51 in Adipocytes Regulates Adipose Tissue Mitochondrial Function and Systemic Metabolism During Aging.Aging cell · 2026Article
- Redox index and capacity analysis (RICA) reveals NAD biology changes in T cell responses in vitro and ex vivo.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Effects of NAD⁺ repletion with Nicotinamide riboside on obesity-induced chronic kidney disease and renal cell lipotoxicity.Scientific reports · 2026Article
- From the cytosol to the inner membrane: biogenesis of the mitochondrial carrier family.Protein science : a publication of the Protein Society · 2026Review
- Aspartate availability drives differential engagement of the malate-aspartate shuttle.Molecular cell · 2026Article
146 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 4 countries.
Timothy S LuongoDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-7621-7992
Jared M EllerDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
Mu-Jie LuDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
Marc NiereDepartment of Biomedicine, University of Bergen, Bergen, Norway.
Fabio RaithDepartment of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg, Germany.
Caroline PerryDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Marc R BornsteinDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Paul OliphintDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA.
Lin WangLewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Princeton University, Princeton, NJ, USA.
Melanie R McReynoldsLewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0001-5427-2739
Marie E MigaudMitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.
Joshua D RabinowitzLewis-Sigler Institute for Integrative Genomics, Department of Chemistry, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-1247-4727
F Brad JohnsonDepartment of Pathology and Laboratory Medicine, Perlman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-7443-7227
Kai JohnssonDepartment of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg, Germany.
Mathias ZieglerDepartment of Biomedicine, University of Bergen, Bergen, Norway.ORCID http://orcid.org/0000-0001-6961-2396
Xiaolu A CambronneDepartment of Molecular Biosciences, University of Texas at Austin, Austin, TX, USA. lulu@austin.utexas.edu.ORCID http://orcid.org/0000-0002-3547-448X
Joseph A BaurDepartment of Physiology and Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. baur@pennmedicine.upenn.edu.ORCID http://orcid.org/0000-0001-8262-6549
University of Pennsylvania · USThe University of Texas at Austin · USPrinceton University · USUniversity of Bergen · NOHeidelberg University · DEMax Planck Institute for Medical Research · DEUSA Mitchell Cancer Institute · US
Funding
VIRAL VECTOR COREP30DK019525 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL A. LAZAR · 1986 to 2026
$48.3MNRSA Training CoreTL1TR001880 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$10.0MTargeting NAD Metabolism to Improve Glucose Homeostasis in Obesity and AgingR01DK098656 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Joseph A. Baur · 2013 to 2026
$6.1MTraining in Muscle Biology and Muscle DiseaseT32AR053461 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI OSTAP, E. MICHAEL · 2006 to 2025
$4.9MGatekeepers of Mitochondrial NAD+DP2GM126897 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI CAMBRONNE, XIAOLU ANG · 2017 to 2021
$2.4MDefining the role of NAD+ in ischemic heart failureF32HL145923 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LUONGO, TIMOTHY SCOTT · 2019 to 2019
$65kNCATS NIH HHS TL1 TR001880NHLBI NIH HHS F32 HL145923NIAMS NIH HHS T32 AR053461NIDDK NIH HHS P30 DK019525NIDDK NIH HHS R01 DK098656NIGMS NIH HHS DP2 GM126897
Abstract
Mitochondria require nicotinamide adenine dinucleotide (NAD
Indexed as
AnimalsBiological TransportCell LineCell RespirationGenetic Complementation TestHumansMiceMitochondriaMitochondrial ProteinsNADNucleotide Transport ProteinsOrganic Cation Transport ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsMitochondrial ProteinsNADNdt1 protein, S cerevisiaeNucleotide Transport ProteinsOrganic Cation Transport ProteinsSaccharomyces cerevisiae Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.