ArticleNeurobiology of aging2020
Age- and memory- related differences in hippocampal gray matter integrity are better captured by NODDI compared to single-tensor diffusion imaging.
Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 46 citations in OpenAlex.
- Tidying up white matter: Neuroplastic transformations in sensorimotor tracts following slackline skill acquisition.Human brain mapping · 2024Trial
- Using diffusion MRI to relate hippocampal subfield microstructure to delayed verbal memory in cognitively intact individuals at genetic risk for developing Alzheimer's disease.Experimental gerontology · 2026Article
- Contributions of Gray Matter Microstructure to Differences in Fluid Cognition and Episodic Memory Across the Healthy Adult Lifespan.Human brain mapping · 2026Article
- Subcortical correlates of developmental language disorder: more than the neostriatum.Brain communications · 2026Article
- Longitudinal non-linear changes in the microstructure of the hippocampal subfields in older adults.Neurobiology of aging · 2025Article
- Tau PET Burden Is Associated With Hippocampal Microstructure and Episodic Memory in Amyloid Positive Older Adults.Hippocampus · 2025Article
- General Microstructure Factor Analysis of Diffusion MRI in Gray-Matter Predicts Cognitive Scores.ArXiv · 2025Article
- Associations between temporal lobe cortical NODDI measures and memory function in individuals without clinical dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Aging of gray matter microstructure: A brain-wide characterization of age group differences using NODDI.Neurobiology of aging · 2025Article
- Independent associations of sleep and physical activity with cognition are mediated by hippocampal microstructure in middle-aged and older adults.Neurobiology of aging · 2025Article
- Advanced diffusion imaging in grey matter reflects individual differences in cognitive ability in older adults.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Thalamus involvement in genetic frontotemporal dementia assessed using structural and diffusion MRI: a GENFI study.Brain communications · 2025Article
- Microstructure of the cerebellum and its afferent pathways underpins dystonia in myoclonus dystonia.European journal of neurology · 2024Article
- The Common Marmoset as a Translational Model for Longitudinal Studies of Cognitive Aging and Individual Vulnerability to Decline.bioRxiv : the preprint server for biology · 2024Article
- Locus coeruleus contrast and diffusivity metrics differentially relate to age and memory performance.Scientific reports · 2024Article
- Medial temporal lobe gray matter microstructure in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Article
- Purpose in life as a resilience factor for brain health: diffusion MRI findings from the Midlife in the U.S. study.Frontiers in psychiatry · 2024Article
- Acute cycling exercise and hippocampal subfield function and microstructure in healthy older adults.Hippocampus · 2023Article
- The use of neuroimaging techniques in the early and differential diagnosis of dementia.Molecular psychiatry · 2023Review
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4 authors at 2 institutions in 1 country.
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Abstract
Single-tensor diffusion imaging (DTI) has traditionally been used to assess integrity of white matter. For example, we previously showed that integrity of limbic white matter tracts declines in healthy aging and relates to episodic memory performance. However, multi-compartment diffusion models may be more informative about microstructural properties of gray matter. The current study examined hippocampal gray matter integrity using both single-tensor and multi-compartment (neurite orientation dispersion and density imaging, NODDI) diffusion imaging. Younger (20-38 years) and older (59-84 years) adults also completed the Mnemonic Similarity Task to measure mnemonic discrimination performance. Results revealed age-related declines in both single-tensor (lower fractional anisotropy, higher mean diffusivity) and multi-compartment (higher restricted, hindered and free diffusion) measures of hippocampal gray matter integrity. As expected, NODDI measures (hindered and free diffusion) captured more age-related variance than DTI measures. Moreover, mnemonic discrimination of highly similar lure items in memory was related to hippocampal gray matter integrity in younger but not older adults. These findings support the notion that age-related differences in gray matter integrity are better captured by multi-compartment versus single-tensor diffusion models and show that the relationship between mnemonic discrimination and hippocampal gray matter integrity is moderated by age.
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