Evidence map›Paper›PMID 32905767›Full record

ArticleCell reports2020

Cholinergic Synaptic Homeostasis Is Tuned by an NFAT-Mediated α7 nAChR-K

Abdunaser Eadaim, Eu-Teum Hahm, Elizabeth D Justice, Susan Tsunoda

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. ACh Transfers: Homeostatic Plasticity of Cholinergic Synapses.Cellular and molecular neurobiology · 2023
    Review
  4. Article
  5. Article
  6. Slo2/KThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  7. Temporal regulation of nicotinic acetylcholine receptor subunits supports central cholinergic synapse development inProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Abdunaser EadaimDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Eu-Teum HahmDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Elizabeth D JusticeDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Susan TsunodaDepartment of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA. Electronic address: susan.tsunoda@colostate.edu.
Colorado State University · US

Funding

Localization and Regulation of Shal (Kv4) Potassium ChannelsR01GM083335 · NIGMS · COLORADO STATE UNIVERSITY · PI TSUNODA, SUSAN L · 2007 to 2021
$3.8M
Synaptic Homeostasis Modulated by Kv4R01NS108958 · NINDS · COLORADO STATE UNIVERSITY · PI TSUNODA, SUSAN L · 2019 to 2023
$328k
NIGMS NIH HHS R01 GM083335NINDS NIH HHS R01 NS108958
6 · The paper itself

Abstract

Homeostatic synaptic plasticity (HSP) involves compensatory mechanisms employed by neurons and circuits to preserve signaling when confronted with global changes in activity that may occur during physiological and pathological conditions. Cholinergic neurons, which are especially affected in some pathologies, have recently been shown to exhibit HSP mediated by nicotinic acetylcholine receptors (nAChRs). In Drosophila central neurons, pharmacological blockade of activity induces a homeostatic response mediated by the Drosophila α7 (Dα7) nAChR, which is tuned by a subsequent increase in expression of the voltage-dependent K

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorAnimalsDrosophila ProteinsHomeostasisShal Potassium ChannelsSynaptic Transmissionalpha7 Nicotinic Acetylcholine ReceptorDrosophila ProteinsShal Potassium ChannelsShal protein, Drosophilaactivity-dependentcholinergic signalingDrosophilahomeostatic synaptic plasticityK(v)4NACHONFATShalsynaptic homeostasisα7 nAChR

Identifiers

PMID32905767
PMCPMC7521586
OpenAlexW3084263356

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.