Evidence map›Paper›PMID 32905757›Full record

ReviewAnnual review of microbiology2020

Molecular Mechanisms of Drug Resistance in

Kathryn J Wicht, Sachel Mok, David A Fidock

Open access · greenAbstract readReview
In one paragraph

Review in Annual review of microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed, 8 pooled it
22.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

172 citing papers in PubMed, 8 syntheses or guidelines pooled it, 307 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Mapping Antimalarial Drug Resistance in Mozambique: A Systematic Review ofInternational journal of molecular sciences · 2024
    Pooled it
  5. Phosphorylation in theJournal of proteome research · 2024
    Pooled it
  6. Pooled it
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  9. Article
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  17. Selective targeting ofAntimicrobial agents and chemotherapy · 2026
    Article
  18. Article
  19. Article
  20. bioRxiv : the preprint server for biology · 2026
    Article

112 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kathryn J WichtDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, USA; email: kathrynwicht@gmail.com, sm4223@cumc.columbia.edu, df2260@cumc.columbia.edu.
Sachel MokDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, USA; email: kathrynwicht@gmail.com, sm4223@cumc.columbia.edu, df2260@cumc.columbia.edu.
David A FidockDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York 10032, USA; email: kathrynwicht@gmail.com, sm4223@cumc.columbia.edu, df2260@cumc.columbia.edu.
Columbia University Irving Medical Center · US

Funding

Leveraging PfCRT Structure to Discern Function and Predict Emergence of Drug-Resistant MalariaR01AI147628 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock, Filippo Mancia · 2019 to 2026
$5.1M
Defining the Role of PfCRT and PfMDR1 as Pleiotropic Mediators of Plasmodium falciparum Multidrug ResistanceR37AI050234 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2018 to 2026
$4.4M
Defining P. falciparum resistance to artemisinin-based combination therapiesR01AI109023 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FIDOCK, DAVID A · 2014 to 2025
$4.4M
Elucidating the molecular basis of piperaquine resistance in Plasmodium falciparumR01AI124678 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2016 to 2026
$4.3M
NIAID NIH HHS R01 AI109023NIAID NIH HHS R01 AI124678NIAID NIH HHS R01 AI147628NIAID NIH HHS R37 AI050234
6 · The paper itself

Abstract

Understanding and controlling the spread of antimalarial resistance, particularly to artemisinin and its partner drugs, is a top priority.

Indexed as

AntimalarialsArtemisininsChloroquineDrug ResistanceHumansMalaria, FalciparumMembrane Transport ProteinsMutationPlasmodium falciparumProtozoan ProteinsQuinolinesAntimalarialsartemisininArtemisininsChloroquineMembrane Transport ProteinsPfCRT protein, Plasmodium falciparumProtozoan ProteinsquinolineQuinolinesantimalarial drug resistanceartemisinin-based combination therapyendocytosishemoglobink13pfcrtpiperaquinetransport

Identifiers

PMID32905757
PMCPMC8130186
OpenAlexW3084158514

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.