Evidence map›Paper›PMID 32905537›Full record

ArticleAmerican journal of cancer research2020

Transcriptomic and functional pathway features were associated with survival after pathological complete response to neoadjuvant chemotherapy in breast cancer.

Takashi Takeshita, Li Yan, Xuan Peng, Siker Kimbung, Thomas Hatschek, Ingrid A Hedenfalk, Omar M Rashid, Kazuaki Takabe

Open access · greenAbstract read
In one paragraph

Article in American journal of cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Takashi TakeshitaBreast Surgery, Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center Buffalo, NY, USA.
Li YanDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center Buffalo, NY, USA.
Xuan PengDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center Buffalo, NY, USA.
Siker KimbungDivision of Oncology, Department of Clinical Sciences and Lund University Cancer Center, Lund University Lund, Sweden.
Thomas HatschekBreast Center, Karolinska University Hospital and Department of Oncology-Pathology, Karolinska Institutet Solna, Sweden.
Ingrid A HedenfalkDivision of Oncology, Department of Clinical Sciences and Lund University Cancer Center, Lund University Lund, Sweden.
Omar M RashidHoly Cross Hospital Michael and Dianne Bienes Comprehensive Cancer Center Fort Lauderdale, Florida, USA.
Kazuaki TakabeBreast Surgery, Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center Buffalo, NY, USA.
Roswell Park Comprehensive Cancer Center · US

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6M
Sphingosine-1 Phosphate in Breast Cancer Progression and LymphangiogenesisR01CA160688 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI TAKABE, KAZUAKI · 2012 to 2016
$1.5M
NCI NIH HHS P30 CA016056NCI NIH HHS R01 CA160688
6 · The paper itself

Abstract

Pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) has been proposed as a surrogate endpoint for the prediction of long-term survival in breast cancer (BC); however, an increased pCR rate has not clearly correlated with improved survival. We hypothesized that some transcriptomic and functional pathway features correlate with survival after pCR in BC. We utilized 2 published NAC cohorts, 105 women with gene expression data before, "Baseline", and that changed during NAC, "Delta", and TCGA database with 1068 BC patients to investigate the relationship between the efficacy of NAC and survival utilizing differentially expressed-mRNAs, construction and analysis of the mRNA-hub gene network, and functional pathway analysis. In mRNA expression profiling,

Indexed as

bioinformaticsBreast cancercancer genomicsfunctional pathwaypCR and survival

Identifiers

PMID32905537
PMCPMC7471342
OpenAlexW3085516345

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.