Evidence map›Paper›PMID 32905508›Full record

ArticleAmerican journal of cancer research2020

Two engineered site-specific antibody-drug conjugates, HLmD4 and HLvM4, have potent therapeutic activity in two DLL4-positive tumour xenograft models.

Shijing Wang, Hui Wen, Wenyi Fei, Yuhong Zhao, Yuqi Feng, Lu Kuang, Min Wang, Min Wu

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in American journal of cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Shijing WangState Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University Nanjing 210009, China.
Hui WenState Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University Nanjing 210009, China.
Wenyi FeiState Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University Nanjing 210009, China.
Yuhong ZhaoState Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University Nanjing 210009, China.
Yuqi FengState Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University Nanjing 210009, China.
Lu KuangState Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University Nanjing 210009, China.
Min WangState Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University Nanjing 210009, China.
Min WuState Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University Nanjing 210009, China.
China Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The humanized Delta-like 4 (DLL4) monoclonal antibody H3L2 with a quite high affinity for hrDLL4 inhibits the DLL4-mediated human umbilical vein endothelial cell (HUVEC) phenotype, inducing dysfunctional angiogenesis and tumour cell apoptosis, which effectively arrests breast cancer cell growth

Indexed as

antibody-drug conjugatesDLL4DM1specific-sitetumour models

Identifiers

PMID32905508
PMCPMC7471348
OpenAlexW3086702451

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.