Evidence map›Paper›PMID 32905494›Full record

ArticleAmerican journal of cancer research2020

Novel genetic variants of

Lihua Liu, Hongliang Liu, Sheng Luo, Edward F Patz, Carolyn Glass, Li Su, Lijuan Lin, David C Christiani, Qingyi Wei

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Genetic Variants ofJournal of hepatocellular carcinoma · 2025
    Article
  2. Article
  3. Advances in lymphatic metastasis of non-small cell lung cancer.Cell communication and signaling : CCS · 2024
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Lihua LiuDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University Nanning, Guangxi 530021, China.
Hongliang LiuDuke Cancer Institute, Duke University Medical Center Durham, NC 27710, USA.
Sheng LuoDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine Durham, NC 27710, USA.
Edward F PatzDuke Cancer Institute, Duke University Medical Center Durham, NC 27710, USA.
Carolyn GlassDuke Cancer Institute, Duke University Medical Center Durham, NC 27710, USA.
Li SuDepartments of Environmental Health and Epidemiology, Harvard School of Public Health Boston, MA, 02115 USA.
Lijuan LinDepartments of Environmental Health and Epidemiology, Harvard School of Public Health Boston, MA, 02115 USA.
David C ChristianiDepartments of Environmental Health and Epidemiology, Harvard School of Public Health Boston, MA, 02115 USA.
Qingyi WeiDuke Cancer Institute, Duke University Medical Center Durham, NC 27710, USA.
Harvard University · USDuke Medical Center · USDuke University · US

Funding

Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI JOHN N. NORTON · 1985 to 2026
$174.8M
The Boston Lung Cancer Survival CohortU01CA209414 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI David C Christiani · 2017 to 2026
$12.2M
Translational studies of Hsp90 inhibitors in NSCLCP50CA090578 · NCI · DANA-FARBER CANCER INST · PI YEAP, BEOW Y · 2008 to 2012
$11.4M
Molecular and Genetic Analysis of Lung Cancer SurvivalR01CA092824 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTIANI, DAVID C · 2002 to 2013
$5.9M
SPORE in Lung CancerP20CA090578 · NCI · DANA-FARBER CANCER INSTITUTE · PI JOHNSON, BRUCE E. · 2003 to 2007
$5.1M
GENETIC SUSCEPTIBILITY TO LUNG CANCERR01CA074386 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTIANI, DAVID C · 1997 to 2008
$4.8M
Statistical Methods for Clinical Trials with Multivariate Longitudinal OutcomesR01NS091307 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LUO, SHENG · 2015 to 2018
$1.2M
Shared genetic, epigenetic, and transcriptomic profiles between AD and PTSD: molecular insights into the heterogeneity of neuropsychiatric symptoms in Alzheimers DiseaseR56AG062302 · NIA · DUKE UNIVERSITY · PI CHIBA-FALEK, ORNIT, LUO, SHENG · 2018 to 2018
$788k
NCI NIH HHS P20 CA090578NCI NIH HHS P30 CA014236NCI NIH HHS P50 CA090578NCI NIH HHS R01 CA074386NCI NIH HHS R01 CA092824NCI NIH HHS U01 CA209414NIA NIH HHS R56 AG062302NINDS NIH HHS R01 NS091307
6 · The paper itself

Abstract

Although lymphangiogenesis is a vital step in lung cancer metastasis, the association between lymphangiogenesis and non-small cell lung cancer (NSCLC) survival remains unclear. Since single-nucleotide polymorphisms (SNPs) have been reported to predict NSCLC survival, we investigated associations between SNPs in lymphangiogenesis-related pathway genes and NSCLC survival in a discovery genotyping dataset of 1,185 patients from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial and validated the findings in another genotyping dataset of 984 patients from the Harvard Lung Cancer Susceptibility Study. We evaluated associations between 34,509 genetic variants (3252 genotyped and 31,257 imputed) in 247 genes involved in lymphangiogenesis-related pathway and NSCLC survival. After validation, we finally identified two independent SNPs (

Indexed as

lymphangiogenesisNon-small cell lung cancersingle-nucleotide polymorphismsurvival

Identifiers

PMID32905494
PMCPMC7471352
OpenAlexW3085974216

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.