Evidence map›Paper›PMID 32905416›Full record

ArticleAmerican journal of cancer research2020

Preclinical investigation of ovatodiolide as a potential inhibitor of colon cancer stem cells via downregulating sphere-derived exosomal β-catenin/STAT3/miR-1246 cargoes.

Yan-Jiun Huang, Tse-Hung Huang, Vijesh Kumar Yadav, Maryam Rachmawati Sumitra, David Tw Tzeng, Po-Li Wei, Jing-Wen Shih, Alexander Th Wu

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Exosomes in bridging macrophage-fibroblast polarity and cancer stemness.Medical oncology (Northwood, London, England) · 2025
    Review
  6. Regulation of Cancer Stem Cells in the Tumor Microenvironment.Cancer heterogeneity and plasticity · 2025
    Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Innovative Purification Method of Ovatodiolide fromMolecules (Basel, Switzerland) · 2022
    Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yan-Jiun HuangDivision of Colorectal Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei Medical University Taipei 110, Taiwan.
Tse-Hung HuangDepartment of Traditional Chinese Medicine, Chang Gung Memorial Hospital Keelung 204, Taiwan.
Vijesh Kumar YadavThe Program for Translational Medicine, Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University Taipei 110, Taiwan.
Maryam Rachmawati SumitraGraduate Institute for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 110, Taiwan.
David Tw TzengSchool of Life Sciences, The Chinese University of Hong Kong Hong Kong, China.
Po-Li WeiDivision of Colorectal Surgery, Department of Surgery, Taipei Medical University Hospital, Taipei Medical University Taipei 110, Taiwan.
Jing-Wen ShihGraduate Institute for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University Taipei 110, Taiwan.
Alexander Th WuThe Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University Taipei 110, Taiwan.
Taipei Medical University · TWChang Gung Memorial Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with advanced-stage colon cancer often exhibit resistance against treatment and distant metastasis, both key contributors to poor prognosis. Emerging evidence indicates that cancer stem cells (CSCs), characterized by the enhanced ability to self-renew, resist therapeutics, and promote metastasis, represents a clinical challenge to target. Alternative therapeutic approaches are urgently required. Here, we explored the feasibility of disrupting the intracellular communications between CSCs and the tumor microenvironment by way of exosomes. First, we demonstrated that exosomes secreted by colon tumorspheres (Exo

Indexed as

5-FU resistanceand ovatodiolideColon cancer stem cellstumor microenvironmenttumorsphere derived exosomesβ-catenin/STAT3/miR-1246 signaling

Identifiers

PMID32905416
PMCPMC7471366
OpenAlexW3085419649

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.