Evidence map›Paper›PMID 32905409›Full record

ArticleJournal of experimental nephrology2020

Beneficial effects of nicotinamide on hypertensive mice with impaired endothelial nitric oxide function.

Phillip K Huynh, Jen Wilder, Sylvia Hiller, John Hagaman, Nobuyuki Takahashi, Nobuyo Maeda-Smithies, Feng Li

Open access · greenAbstract read
In one paragraph

Article in Journal of experimental nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. NADCell communication and signaling : CCS · 2024
    Review
  3. Nicotinamide Mononucleotide: Research Process in Cardiovascular Diseases.International journal of molecular sciences · 2024
    Review
  4. Article
  5. NADAntioxidants (Basel, Switzerland) · 2023
    Review
  6. Article
  7. NADJournal of lipid and atherosclerosis · 2022
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Phillip K HuynhDepartment of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Jen WilderDepartment of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Sylvia HillerDepartment of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
John HagamanDepartment of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Nobuyuki TakahashiDivision of Clinical Pharmacology and Therapeutics, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan.
Nobuyo Maeda-SmithiesDepartment of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Feng LiDepartment of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
University of North Carolina at Chapel Hill · USTohoku University · JP

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
MODELS FOR STUDYING THE GENETICS OF HYPERTENSIONR01HL049277 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAEDA, NOBUYO · 1992 to 2025
$17.5M
NHLBI NIH HHS R01 HL049277NIDDK NIH HHS P30 DK034987
6 · The paper itself

Abstract

Nicotinamide (Nam, amide form of niacin acid or nicotinate), a precursor for nicotinamide adenine dinucleotide (NAD+), is important for normal physiological function of organisms. Nam also suppresses mobilization of Ca

Indexed as

Blood pressureEndothelial nitric oxide synthaseL-NAMEMiceNicotinamide

Identifiers

PMID32905409
PMCPMC7470241
OpenAlexW3086207604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.