Evidence map›Paper›PMID 32905350›Full record

ArticleCoordination chemistry reviews2020

Sulfhydryl groups as targets of mercury toxicity.

Olga P Ajsuvakova, Alexey A Tinkov, Michael Aschner, João B T Rocha, Bernhard Michalke, Margarita G Skalnaya, Anatoly V Skalny, Monica Butnariu, Maryam Dadar, Ioan Sarac and 2 more

Open access · greenAbstract read
In one paragraph

Article in Coordination chemistry reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 4 pooled it
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 4 syntheses or guidelines pooled it, 328 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Toxicological evidence that methylmercury exposure amplifies bone destruction and systemic impact associated with apical periodontitis in rats.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Mercury in Retrograde: The Tale of Toxicity.Case reports in nephrology · 2026
    Article
  17. Review
  18. Article
  19. Article
  20. Article

38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 7 countries.

Olga P AjsuvakovaYaroslavl State University, Yaroslavl, Russia.
Alexey A TinkovYaroslavl State University, Yaroslavl, Russia.
Michael AschnerIM Sechenov First Moscow State Medical University, Moscow, Russia.
João B T RochaDepartamento de Bioquímica e Biologia Molecular, CCNE, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
Bernhard MichalkeHelmholtz Zentrum München, Neuherberg, Germany.
Margarita G SkalnayaYaroslavl State University, Yaroslavl, Russia.
Anatoly V SkalnyYaroslavl State University, Yaroslavl, Russia.
Monica ButnariuBanat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timișoara, Timişoara, Romania.
Maryam DadarRazi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.
Ioan SaracBanat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timișoara, Timişoara, Romania.
Jan AasethIM Sechenov First Moscow State Medical University, Moscow, Russia.
Geir BjørklundCouncil for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway.
Federal Scientific Center for Biological Systems and Agricultural Technologies of the Russian Academy of Sciences · RUUnivesity of Life Science "King Mihai I" from Timisoara · ROYaroslavl State University · RUAlbert Einstein College of Medicine · USHelmholtz Zentrum München · DERazi Vaccine and Serum Research Institute · IRSechenov University · RUThe Research Council of Norway · NOUniversidade Federal de Santa Maria · BR

Funding

Mechanisms of Manganese NeurotoxicityR01ES010563 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael Aschner, Aaron B Bowman · 2001 to 2026
$11.9M
Mechanisms of Methylmercury Induced Neuron ToxicityR01ES007331 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael Aschner, Aaron B Bowman · 1996 to 2026
$10.6M
Genetic Modulation of MeHg-Induced Oxidative Stress in the Developing BrainR01ES020852 · NIEHS · VANDERBILT UNIVERSITY · PI ASCHNER, MICHAEL · 2012 to 2016
$1.8M
NIEHS NIH HHS R01 ES007331NIEHS NIH HHS R01 ES010563NIEHS NIH HHS R01 ES020852
6 · The paper itself

Abstract

The present study addresses existing data on the affinity and conjugation of sulfhydryl (thiol; -SH) groups of low- and high-molecular-weight biological ligands with mercury (Hg). The consequences of these interactions with special emphasis on pathways of Hg toxicity are highlighted. Cysteine (Cys) is considered the primary target of Hg, and link its sensitivity with thiol groups and cellular damage.

Indexed as

ApoptosisConjugatesCysteineMercuryS-mercuration

Identifiers

PMID32905350
PMCPMC7470069
OpenAlexW3021193787

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.