Evidence map›Paper›PMID 32905245›Full record

ArticleClinical kidney journal2020

Epicardial fat, cardiovascular risk factors and calcifications in patients with chronic kidney disease.

Turgay Saritas, Sebastian Daniel Reinartz, Jennifer Nadal, Jonas Schmoee, Matthias Schmid, Mohamed Marwan, Stephan Achenbach, Stefan Störk, Christoph Wanner, Kai-Uwe Eckardt and 3 more

Open access · goldAbstract read
In one paragraph

Article in Clinical kidney journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Turgay SaritasDepartment of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany.ORCID 0000-0002-6691-9218
Sebastian Daniel ReinartzDepartment of Diagnostic and Interventional Radiology, University Hospital RWTH Aachen, Aachen, Germany.
Jennifer NadalDepartment of Medical Biometry, Informatics, and Epidemiology (IMBIE), University Hospital Bonn, Bonn, Germany.
Jonas SchmoeeDepartment of Diagnostic and Interventional Radiology, University Hospital RWTH Aachen, Aachen, Germany.
Matthias SchmidDepartment of Medical Biometry, Informatics, and Epidemiology (IMBIE), University Hospital Bonn, Bonn, Germany.
Mohamed MarwanDepartment of Cardiology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Stephan AchenbachDepartment of Cardiology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Stefan StörkDivision of Cardiology (Comprehensive Heart Failure Center), Department of Medicine I, University Hospital Würzburg, Würzburg, Germany.
Christoph WannerDivision of Nephrology, Department of Medicine, University Hospital Würzburg, Würzburg, Germany.
Kai-Uwe EckardtDepartment of Nephrology and Medical Intensive Care, Charité Universitätsmedizin Berlin, Berlin, Germany.
Jürgen FloegeDepartment of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany.
Markus Peter SchneiderDepartment of Nephrology and Hypertension, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Georg SchlieperDepartment of Nephrology and Clinical Immunology, University Hospital RWTH Aachen, Aachen, Germany.ORCID 0000-0001-6050-5842
RWTH Aachen University · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversitätsklinikum Würzburg · DEUniversity Hospital Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpicardial adipose tissue (EAT) exerts cardiopathogenic effects, but the independent association between EAT and cardiovascular (CV) calcification in patients with chronic kidney disease (CKD) remains controversial. We therefore assessed the association between EAT, CV risk factors and CV calcifications.

methods257 patients with CKD Stage 3 and/or overt proteinuria underwent quantification of EAT, coronary artery calcification and aortic valve calcification by computed tomography. Framingham and American College of Cardiology and American Heart Association (ACC-AHA) 10-year CV event risk scores were calculated for each patient.

resultsUsing multivariable regression analysis, higher EAT was significantly associated with the majority of investigated risk factors {higher age: odds ratio [OR] 1.05/year [95% confidence interval (CI) 1.02-1.08]; male sex: OR 4.03 [95% CI 2.22-7.31]; higher BMI: OR 1.28/kg/m

conclusionsThe increase of EAT can be explained by individual CV risk factors and kidney function and correlates with 10-year risk for CV event scores, suggesting that EAT is a modifiable risk factor in patients with CKD. Although EAT correlates with CV calcifications, these relations depend on CV risk factors.

Indexed as

atherosclerotic cardiovascular disease risk scorechronic kidney diseaseepicardial adipose tissueFramingham risk scorevascular calcification

Identifiers

PMID32905245
PMCPMC7467583
OpenAlexW2940117584

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.