ArticleExperimental and therapeutic medicine2020
Angiotensin-converting enzyme gene D-allele and the severity of coronary artery disease.
Article in Experimental and therapeutic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Trial
- New Insights into the Pathophysiology of Coronary Artery Aneurysms.Diagnostics (Basel, Switzerland) · 2024Review
- Predicting early-stage coronary artery disease using machine learning and routine clinical biomarkers improved by augmented virtual data.European heart journal. Digital health · 2024Article
- Association of ACE gene polymorphisms with in-stent restenosis by stent type (biomime, supraflex, xience).Molecular biology reports · 2023Article
- Association betweenFrontiers in cardiovascular medicine · 2023Article
- The Association ofInternational journal of molecular sciences · 2022Article
- Article
- The Renin-Angiotensin System: A Key Role in SARS-CoV-2-Induced COVID-19.Molecules (Basel, Switzerland) · 2021Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronary artery disease (CAD) is the first cause of morbidity and mortality worldwide. An important goal is to diagnose patients in early stages, in order to reduce acute cardiovascular events. The angiotensin-converting enzyme (ACE) is an important element for the cardiovascular system, through its actions on hydro-salin balance and vascular tone. ACE polymorphism consists of insertions (I)/deletions (D) and there are 3 genotypes: II, ID, DD. It is speculated that the DD genotype may be a genetic basis for severe CAD, while the II genotype may have a protective effect on the coronary arteries. The present study included 154 patients with acute coronary syndroms admitted to the Institute for Cardiovascular Disease 'George I.M. Georgescu', Iasi. The patients underwent coronary angiography in order to assess the severity of the lesions and the ACE genotypes were determined for each patient. The genotypes were correlated with the severity of the vessel-disease and the exposure to classic risk factors. It was concluded that the D-allele is associated with a greater risk for acute coronary events and severe coronary stenosis, especially when risk genotype and risk phenotype interact.
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