ReviewClinical reviews in bone and mineral metabolism2020
Bone Metabolism in SARS-CoV-2 Disease: Possible Osteoimmunology and Gender Implications.
Review in Clinical reviews in bone and mineral metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06940609 (Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Magnetic Resonance Analysis of Neural Inflammatory Factors and External Stimulation (MANIFEST)
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Femoral head avascular necrosis in COVID-19 survivors: a systematic review.Rheumatology international · 2023Pooled it
- Complication and Sequelae of COVID-19: What Should We Pay Attention to in the Post-Epidemic Era.Frontiers in immunology · 2021Pooled it
- Multiscale bone remodeling in COVID-19: from osteoimmune signaling to structural and mechanical impairment.Frontiers in bioengineering and biotechnology · 2026Review
- Characteristics of osteonecrosis of the femoral head after COVID-19 steroid treatment compared to steroid-associated osteonecrosis.BMC musculoskeletal disorders · 2025Article
- The Evaluation of New-Generation Biomarker sCD14ST Provides New Insight into COVID-19's Effect on Bone Remodeling.Journal of clinical medicine · 2025Article
- Exploring the landscape of symptom-specific inflammatory cytokines in post-COVID syndrome patients.BMC infectious diseases · 2024Article
- Serum proinflammatory cytokines, receptor activator of nuclear factor kappa-Β ligand (RANKL), osteoprotegerin (OPG) and RANKL/OPG ratio in mild and severe COVID-19.BMC infectious diseases · 2024Article
- Article
- Potential Impact of Long COVID-19 on Orthodontic Treatment.European journal of dentistry · 2024Article
- Acute bone loss following SARS-CoV-2 infection in mice.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Avascular Necrosis of the Hip after the COVID-19 Pandemic.Journal of pharmacy & bioallied sciences · 2023Article
- What factors predict craniomandibular disorders in severe COVID-19 survivors after prolonged intubation?Journal of stomatology, oral and maxillofacial surgery · 2022Article
- SARS-CoV-2 in immunocompromised individuals.Immunity · 2022Review
- Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19.International journal of molecular sciences · 2022Review
- COVID-19 Pandemic and Osteoporosis in Elderly Patients.Aging and disease · 2022Article
- Possible harm from glucocorticoid drugs misuse in the early phase of SARS-CoV-2 infection: a narrative review of the evidence.Internal and emergency medicine · 2022Review
- Pathological sequelae of long-haul COVID.Nature immunology · 2022Review
- Avascular Necrosis Bone Complication after Active COVID-19 Infection: Preliminary Results.Medicina (Kaunas, Lithuania) · 2021Article
- Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling.International journal of molecular sciences · 2021Review
- Attenuation of COVID-19-induced cytokine storm in a young male patient with severe respiratory and neurological symptoms.Wiener klinische Wochenschrift · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Even though inflammatory conditions are known to exert adverse effects on bone metabolism, there are no published data regarding SARS-CoV-2 infection and subsequent fracture risk. We present a brief review of the molecular mechanisms linking inflammatory diseases to increased fracture risk/osteoporosis and of the therapeutic strategies that can prevent bone resorption in patients with inflammatory disease, focusing on the RANK-RANKL system. We also make some considerations on gender differences in infection response and on their implications for survival and for the consequences of COVID-19. Several inflammatory cytokines, especially IL-1, IL-6, and TNF-α, stimulate osteoclast activity, favoring bone resorption through the RANK-RANKL system. Data from the previous SARS-CoV outbreak suggest that the present disease also has the potential to act directly on bone resorption units, although confirmation is clearly needed. Even though the available data are limited, the RANK-RANKL system may provide the best therapeutic target to prevent bone resorption after COVID-19 disease. Vitamin D supplementation in case of deficiency could definitely be beneficial for bone metabolism, as well as for the immune system. Supplementation of vitamin D in case of deficiency could be further advantageous. In COVID-19 patients, it would be useful to measure the bone metabolism markers and vitamin D. Targeting the RANK-RANKL system should be a priority, and denosumab could represent a safe and effective choice. In the near future, every effort should be made to investigate the fracture risk after SARS-CoV-2 infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.