ArticleClinical interventions in aging2020
Alveolar Bone Loss, Tooth Loss and Oral Cancer Mortality in Older Patients: A Retrospective Cohort Study.
Article in Clinical interventions in aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Efficacy of maxillary occlusal splints on mobile posterior teeth in patients with stage III or IV periodontitis during steps 1 and 2 of periodontal therapy: a randomized parallel-controlled clinical trial.Clinical oral investigations · 2025Trial
- Salivary Biomarkers as Prognostic Tools in Oral Squamous Cell Carcinoma: A Systematic Review of Survival and Progression Outcomes.Dentistry journal · 2025Review
- Association between the number of teeth and all-cause mortality rate in the MASHAD Cohort Study.Journal of dental research, dental clinics, dental prospects · 2025Article
- Article
- Periodontitis and dental quality of life predict long-term survival in head and neck cancer.BMC oral health · 2024Article
- Association of oral health with all-cause and cause-specific mortality in older Chinese adults: A 14-year follow-up of the Guangzhou Biobank Cohort study.Journal of global health · 2024Article
- Alveolar bone loss and tooth loss contribute to increase in cancer mortality among older patients.BMC oral health · 2023Article
- The mortality of oral cancer attributable to tobacco in China, the US, and India.Journal of cancer research and clinical oncology · 2023Article
- Tooth loss, denture use, and all-cause and cause-specific mortality in older adults: a community cohort study.Frontiers in public health · 2023Article
- [Oral Microbiome and Systemic Diseases].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Review
- Periodontitis as a risk for oral cancer: a case-control study.BMC oral health · 2021Article
- Oral Equilibrium in Cachexia.Asia-Pacific journal of oncology nursingReview
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThere has been growing interest in the association between periodontitis and systemic disease. In recent years, however, inconsistent results have also been found by case-control studies for the role of periodontitis in the development of oral cancer. This study aimed to examine whether periodontitis was an independent risk factor for oral cancer with a ≥75-year age group cohort. MATERIALS AND
methodsBetween January 2010 and December 2014, 1385 patients aged ≥75 years who underwent radiographic examination were included in this retrospective cohort study. We collected demographic information and comorbid health conditions from local health authorities. Participants were followed up until either the occurrence of mortality, or the end of the study on December 31, 2018. Cox proportional hazards regression and competing risk hazard models were used to examine the association between periodontitis and oral cancer mortality.
resultsPeriodontitis and loss of teeth were significantly associated with oral cancer mortality. Compared to oral cancer mortality in healthy subjects, the HR and 95% CI in patients with mild, moderate, and severe periodontitis were 4.46 (0.94-21.06), 5.16 (1.14-23.39), and 6.65 (1.51-29.36), respectively. The HR (95% CI) was 1.05 (1.01-1.09) for tooth loss after controlling for potential confounding factors. All the increases in risk persisted in patients aged ≥80 years.
conclusionThe present study provides substantial evidence that poor periodontal health is associated with oral cancer mortality. It is necessary to underline the importance of considering periodontitis in the prevention of oral cancer, particularly in the older patients.
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