ArticleCell reports. Medicine2020
Robust T Cell Response Toward Spike, Membrane, and Nucleocapsid SARS-CoV-2 Proteins Is Not Associated with Recovery in Critical COVID-19 Patients.
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Article in Cell reports. Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers.
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126citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
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Who cites it
126 citing papers in PubMed, 188 citations in OpenAlex.
- Single dose of BNT162b2 mRNA vaccine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) induces neutralising antibody and polyfunctional T-cell responses in patients with chronic myeloid leukaemia.British journal of haematology · 2021Trial
- Article
- Coordinated immune response distinguishes duration of SARS-CoV-2 viral particle shedding in humans.iScience · 2026Article
- A new mRNA antigen vaccine induces potent B and T cell responses and in vivo protection against SARS-CoV-2.NPJ vaccines · 2026Article
- A new mRNA antigen vaccine induces potent B and T cell responses andbioRxiv : the preprint server for biology · 2026Article
- Homoeriodictyol, targeting the bitter taste receptor TAS2R14, lowers the secretion of pro-inflammatory chemokines upon treatment with SARS-CoV-2 peptide pools in human peripheral blood mononuclear cells.Frontiers in immunology · 2026Article
- COVID-19 mRNA or viral vector vaccine type and subject sex influence the SARS-CoV-2 T-cell response.Vaccine · 2025Article
- NOD2 (Nucleotide-Binding Oligomerization Domain-Containing Protein 2)-Mediated Modulation of the Immune Response Induced by BCG (Bacillus Calmette-Guérin) Bacilli.Pathogens (Basel, Switzerland) · 2025Article
- Patients With Mild COVID-19 Exhibit Low Functional Avidity of SARS-CoV-2 Membrane Protein-Reactive CD4Immune network · 2025Article
- The Impact of Vaccination Frequency on COVID-19 Public Health Outcomes: A Model-Based Analysis.Vaccines · 2025Article
- Role of Ferroptosis in the Progression of COVID-19 and the Development of Long COVID.Current medicinal chemistry · 2025Article
- T cell-mediated Immune response and correlates of inflammation and their relationship with COVID-19 clinical severity: not an intuitive guess.BMC infectious diseases · 2024Article
- Innate Responses to the Former COVID-19 Vaccine Candidate CVnCoV and Their Relation to Reactogenicity and Adaptive Immunogenicity.Vaccines · 2024Article
- Post-pandemic memory T cell response to SARS-CoV-2 is durable, broadly targeted, and cross-reactive to the hypermutated BA.2.86 variant.Cell host & microbe · 2024Article
- Enhanced detection of antigen-specific T cells by a multiplexed AIM assay.Cell reports methods · 2024Article
- High frequencies of alpha common cold coronavirus/SARS-CoV-2 cross-reactive functional CD4Frontiers in immunology · 2024Article
- Clonal structure and the specificity of vaccine-induced T cell response to SARS-CoV-2 Spike protein.Frontiers in immunology · 2024Article
- Cross-protection induced by highly conserved human B, CD4Frontiers in immunology · 2024Article
- Fading SARS-CoV-2 humoral VOC cross-reactivity and sustained cellular immunity in convalescent children and adolescents.BMC infectious diseases · 2023Article
- SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection.Virologica Sinica · 2023Article
66 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
22 authors at 5 institutions in 1 country.
Constantin J ThiemeCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, BIH Center for Regenerative Therapies, Berlin, Berlin, Germany.
Moritz AnftRuhr-University Bochum, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Center for Translational Medicine and Immune Diagnostics Laboratory, Medical Department I, Herne, North Rhine-Westphalia, Germany.
Krystallenia PaniskakiRuhr-University Bochum, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Center for Translational Medicine and Immune Diagnostics Laboratory, Medical Department I, Herne, North Rhine-Westphalia, Germany.
Arturo Blazquez-NavarroCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, BIH Center for Regenerative Therapies, Berlin, Berlin, Germany.
Adrian DoevelaarRuhr-University Bochum, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Center for Translational Medicine and Immune Diagnostics Laboratory, Medical Department I, Herne, North Rhine-Westphalia, Germany.
Felix S SeibertRuhr-University Bochum, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Center for Translational Medicine and Immune Diagnostics Laboratory, Medical Department I, Herne, North Rhine-Westphalia, Germany.
Bodo HoelzerRuhr-University Bochum, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Center for Translational Medicine and Immune Diagnostics Laboratory, Medical Department I, Herne, North Rhine-Westphalia, Germany.
Margarethe Justine KonikUniversity Duisburg-Essen, University Hospital Essen, Department of Infectious Diseases, West-German Centre for Infectious Diseases, Essen, North Rhine-Westphalia, Germany.
Marc Moritz BergerUniversity Duisburg-Essen, University Hospital Essen, Department of Anesthesiology and Intensive Care Medicine, Essen, North Rhine-Westphalia, Germany.
Thorsten BrennerUniversity Duisburg-Essen, University Hospital Essen, Department of Anesthesiology and Intensive Care Medicine, Essen, North Rhine-Westphalia, Germany.
Clemens TempferRuhr-University Bochum, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Department of Gynecology and Obstetrics, Herne, North Rhine-Westphalia, Germany.
Carsten WatzlLeibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund (IfADo), Department of Immunology Dortmund, North Rhine-Westphalia, Germany.
Toni L MeisterRuhr-University Bochum, Department of Molecular and Medical Virology, Bochum, North Rhine-Westphalia, Germany.
Stephanie PfaenderRuhr-University Bochum, Department of Molecular and Medical Virology, Bochum, North Rhine-Westphalia, Germany.
Eike SteinmannRuhr-University Bochum, Department of Molecular and Medical Virology, Bochum, North Rhine-Westphalia, Germany.
Sebastian DolffUniversity Duisburg-Essen, University Hospital Essen, Department of Infectious Diseases, West-German Centre for Infectious Diseases, Essen, North Rhine-Westphalia, Germany.
Ulf DittmerUniversity Duisburg-Essen, University Hospital Essen, Institute for Virology, Essen, North Rhine-Westphalia, Germany.
Timm H WesthoffRuhr-University Bochum, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Center for Translational Medicine and Immune Diagnostics Laboratory, Medical Department I, Herne, North Rhine-Westphalia, Germany.
Oliver WitzkeUniversity Duisburg-Essen, University Hospital Essen, Department of Infectious Diseases, West-German Centre for Infectious Diseases, Essen, North Rhine-Westphalia, Germany.
Ulrik StervboRuhr-University Bochum, Marien Hospital Herne, University Hospital of the Ruhr-University Bochum, Center for Translational Medicine and Immune Diagnostics Laboratory, Medical Department I, Herne, North Rhine-Westphalia, Germany.
Toralf RochCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, BIH Center for Regenerative Therapies, Berlin, Berlin, Germany.
Nina BabelCharité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, BIH Center for Regenerative Therapies, Berlin, Berlin, Germany.
Universitätsklinik Marien Hospital Herne · DEEssen University Hospital · DEHumboldt-Universität zu Berlin · DERuhr University Bochum · DETU Dortmund University · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
T cell immunity toward SARS-CoV-2 spike (S-), membrane (M-), and nucleocapsid (N-) proteins may define COVID-19 severity. Therefore, we compare the SARS-CoV-2-reactive T cell responses in moderate, severe, and critical COVID-19 patients and unexposed donors. Overlapping peptide pools of all three proteins induce SARS-CoV-2-reactive T cell response with dominance of CD4
Indexed as
AdultAgedAged, 80 and overConvalescenceCoronavirus M ProteinsCoronavirus Nucleocapsid ProteinsCOVID-19Critical IllnessFemaleHumansMaleMiddle AgedPhosphoproteinsSARS-CoV-2Spike Glycoprotein, CoronavirusT-LymphocytesCoronavirus M ProteinsCoronavirus Nucleocapsid Proteinsmembrane protein, SARS-CoV-2nucleocapsid phosphoprotein, SARS-CoV-2PhosphoproteinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2COVID-19critical COVID-19immunityimmunopathologynucleocapsidSARS-CoV-2S/M/N protein-reactive T cellsspike
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