Evidence map›Paper›PMID 32904434›Full record

ArticleInternational journal of nanomedicine2020

Anti-Metastatic Effect of Gold Nanoparticle-Conjugated

Sun Young Park, Beomjin Kim, Zhengwei Cui, Geuntae Park, Young-Whan Choi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sun Young ParkBio-IT Fusion Technology Research Institute, Pusan National University, Busan 609-735, Korea.
Beomjin KimDepartment of Nanomaterials Engineering, Pusan National University, Busan 609-735, Korea.
Zhengwei CuiDepartment of Horticultural Bioscience, Pusan National University, Myrang 627-706, Korea.
Geuntae ParkDepartment of Nanofusion Technology, Graduate School, Pusan National University, Busan, 609-735, Korea.ORCID 0000-0002-6664-3557
Young-Whan ChoiDepartment of Horticultural Bioscience, Pusan National University, Myrang 627-706, Korea.
Pusan National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe aimed to study green-synthesized gold nanoparticles (GNPs) from

methodsWe quantified the phenolic and flavonoid contents, reducing capacity, and antioxidant activity of all four extracts. The facile and optimum synthesis of MT-GNPs was visualized using UV-vis spectra and dynamic light scattering (DLS). Surface morphology, selected area electron diffraction (SAED), and fast Fourier transform (FFT) pattern of MT-GNPs were assessed using high-resolution transmission electron microscopy (HR-TEM). The crystallized gold pattern of MT-GNPs was evaluated using energy dispersive spectroscopy (EDS) and X-ray diffraction (XRD). The functionalizing ligands of MT-extracts and MT-GNPs were determined using Fourier-transform infrared spectroscopy (FT-IR). The photocatalytic capabilities of MT-GNPs were assessed by measuring the reduction of rhodamine B and methylene blue. Cell viability assay was detected using Cell Counting Kit-8 solution. Anti-migratory and anti-invasive effects were assessed using cell migration and invasion assays. Matrix metalloproteinase (MMP)-9 and phospholipase D (PLD) enzymatic activities were measured using gelatin zymography and Amplex Red PLD assay, respectively. Western blotting and luciferase assay were used to detect protein expression.

resultsAll extracts had high phenolic and flavonoid contents and strong antioxidant and reducing capacities. Results from UV-Vis spectra, DLS, HR-TEM, EDS, XRD, and FT-IR showed the successful formation of MT-GNP with surface morphology, crystallinity, reduction capacity, capsulation, and stabilization. MTR-GNPs and MTS-GNPs had better catalytic activities than MTL-GNPs and MTF-GNPs for reduction of methylene blue and rhodamine B. Moreover, MTS-GNPs and MTR-GNPs exhibited the highest anti-migratory and anti-invasive potential and seemed to be more biologically active than the MTS and MTR extracts. Treatment with MT-GNPs decreased the enzymatic activity, translation levels of MMP-9 and PLD1. Our results showed that MTS-GNPs and MTR-GNPs could dramatically reverse transforming growth factor-β-induced vimentin and N-cadherin upregulation and E-cadherin downregulation.

conclusionThe application of GNPs as a potential treatment approach for hepatocellular carcinoma can improve therapeutic efficiency.

Indexed as

Antineoplastic Agents, PhytogenicAntioxidantsCarcinoma, HepatocellularCell MovementCell SurvivalDynamic Light ScatteringGoldGreen Chemistry TechnologyHep G2 CellsHumansLiver NeoplasmsMacluraMatrix Metalloproteinase 9Metal NanoparticlesMicroscopy, Electron, TransmissionPhospholipase DAntineoplastic Agents, PhytogenicAntioxidantsGoldMatrix Metalloproteinase 9MMP9 protein, humanPhospholipase Dphospholipase D1Plant Extractsepithelial–mesenchymal transitionhepatocellular carcinoma cellsMaclura tricuspidataMT-GNPs

Identifiers

PMID32904434
PMCPMC7455757
OpenAlexW3044506225

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.