Evidence map›Paper›PMID 32904340›Full record

ArticleData in brief2020

Barium blockade of the KcsA channel in open and closed conformation datasets.

Ahmed Rohaim, LiDong Gong, Jing Li, Huan Rui, Lydia Blachowicz, Benoît Roux

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Barrier-Strengthening Effects of Cannabidiol on Porcine Peyer's Patches.International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Ahmed RohaimDepartment of Biochemistry and Molecular Biology, University of Chicago, Gordon Center for Integrative Science, 929 E 57th St, Chicago 60637 IL, United States.
LiDong GongSchool of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China.
Jing LiDepartment of Biochemistry and Molecular Biology, University of Chicago, Gordon Center for Integrative Science, 929 E 57th St, Chicago 60637 IL, United States.
Huan RuiDepartment of Biochemistry and Molecular Biology, University of Chicago, Gordon Center for Integrative Science, 929 E 57th St, Chicago 60637 IL, United States.
Lydia BlachowiczDepartment of Biochemistry and Molecular Biology, University of Chicago, Gordon Center for Integrative Science, 929 E 57th St, Chicago 60637 IL, United States.
Benoît RouxDepartment of Biochemistry and Molecular Biology, University of Chicago, Gordon Center for Integrative Science, 929 E 57th St, Chicago 60637 IL, United States.
University of Chicago · USCairo University · EGLiaoning Normal University · CN

Funding

Computational Studies of Ion Channels - Resubmission 01R01GM062342 · NIGMS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI ROUX, BENOIT · 2001 to 2022
$8.7M
NIGMS NIH HHS R01 GM062342
6 · The paper itself

Abstract

Barium is a potent blocker of the KcsA potassium channel. A strategy using x-ray crystallography and molecular dynamics (MD) simulation has been used to understand this phenomenon as described in Rohaim et al. [1]. Wild type KcsA is purified to homogeneity and crystallized in low and high K

Indexed as

Barium blockCrystallographyIon channelMolecular dynamicsX-ray

Identifiers

PMID32904340
PMCPMC7452694
OpenAlexW3047834788

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.