Complete atrioventricular block and torsade de pointes due to dose-dense epirubicin and cyclophosphamide therapy.

Taiji Okada, Miki Hyakudomi, Kazuto Yamaguchi, Nobuhide Watanabe, Akihiro Endo, Hiroyuki Yoshitomi, Kazuaki Tanabe

Open access · greenAbstract read

In one paragraph

Article in International cancer conference journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.9field-weighted citation impact, top 30% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Taiji OkadaDivision of Cardiology, National Hospital Organization Hamada Medical Center, 777-12 Asaichō, Hamada, Shimane 697-8511 Japan.ORCID 0000-0002-8878-3446

Miki HyakudomiDepartment of Digestive and General Surgery, Shimane University Faculty of Medicine, Hamada, Shimane Japan.

Kazuto YamaguchiDivision of Cardiology, Shimane University Faculty of Medicine, Hamada, Shimane Japan.

Nobuhide WatanabeDivision of Cardiology, Shimane University Faculty of Medicine, Hamada, Shimane Japan.

Akihiro EndoDivision of Cardiology, Shimane University Faculty of Medicine, Hamada, Shimane Japan.

Hiroyuki YoshitomiClinical Laboratory Department, Shimane University Faculty of Medicine, Hamada, Shimane Japan.

Kazuaki TanabeDivision of Cardiology, Shimane University Faculty of Medicine, Hamada, Shimane Japan.

Shimane University · JPNational Hospital Organization · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The dose-dense epirubicin and cyclophosphamide (EC) therapy for breast cancer decreases the risk of cancer recurrence and death. However, epirubicin and cyclophosphamide also cause cardiotoxicity, and cardiomyopathy is the most well-known related adverse effect. A 58-year-old woman presented to our hospital with palpitations 2 weeks after her final dose-dense EC therapy for breast cancer. Holter electrocardiogram (ECG) showed transitory complete atrioventricular block (CAVB) and torsade de pointes. A 12-lead ECG showed QT prolongation in addition to CAVB. Patients receiving dose-dense EC therapy should be monitored more carefully with ECG due to their risk of fatal arrhythmias.

Indexed as

Breast cancerComplete atrioventricular blockDose-dense epirubicin and cyclophosphamide therapyQT prolongationTorsade de pointes

Identifiers

PMID32904147

DOI10.1007/s13691-020-00427-1

PMCPMC7450030

OpenAlexW3036118904

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.