Evidence map›Paper›PMID 32904110›Full record

ArticleInternational cancer conference journal2020

A long-term survival case of unresectable gastric cancer with multidisciplinary therapy including immunotherapy and abscopal effect.

Yuta Kuhara, Motoki Ninomiya, Satoshi Hirahara, Hirofumi Doi, Shirakawa Kenji, Kazuhiro Toyota, Raita Yano, Hironori Kobayashi, Yasushi Hashimoto, Yujiro Yokoyama and 2 more

Open access · greenAbstract readCase Reports
In one paragraph

Article in International cancer conference journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Various therapeutic effects of immune checkpoint inhibitors.International cancer conference journal · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Yuta KuharaDepartment of Surgery, Hiroshima Memorial Hospital, 1-4-3, Honkawatyo, Nakaku, Hiroshima, Hiroshimashi Japan.ORCID 0000-0002-3420-4525
Motoki NinomiyaDigestive Disease Center, Hiroshima Memorial Hospital, Hiroshima, Japan.
Satoshi HiraharaDepartment of Surgery, Hiroshima Memorial Hospital, 1-4-3, Honkawatyo, Nakaku, Hiroshima, Hiroshimashi Japan.
Hirofumi DoiDepartment of Surgery, Hiroshima Memorial Hospital, 1-4-3, Honkawatyo, Nakaku, Hiroshima, Hiroshimashi Japan.
Shirakawa KenjiDepartment of Surgery, Hiroshima Memorial Hospital, 1-4-3, Honkawatyo, Nakaku, Hiroshima, Hiroshimashi Japan.
Kazuhiro ToyotaDepartment of Surgery, Hiroshima Memorial Hospital, 1-4-3, Honkawatyo, Nakaku, Hiroshima, Hiroshimashi Japan.
Raita YanoDepartment of Surgery, Hiroshima Memorial Hospital, 1-4-3, Honkawatyo, Nakaku, Hiroshima, Hiroshimashi Japan.
Hironori KobayashiDepartment of Surgery, Hiroshima Memorial Hospital, 1-4-3, Honkawatyo, Nakaku, Hiroshima, Hiroshimashi Japan.
Yasushi HashimotoDepartment of Surgery, Hiroshima Memorial Hospital, 1-4-3, Honkawatyo, Nakaku, Hiroshima, Hiroshimashi Japan.
Yujiro YokoyamaDepartment of Surgery, Hiroshima Memorial Hospital, 1-4-3, Honkawatyo, Nakaku, Hiroshima, Hiroshimashi Japan.
Yoshihiro SakashitaDepartment of Surgery, Hiroshima Memorial Hospital, 1-4-3, Honkawatyo, Nakaku, Hiroshima, Hiroshimashi Japan.
Katsunari MiyamotoDepartment of Surgery, Hiroshima Memorial Hospital, 1-4-3, Honkawatyo, Nakaku, Hiroshima, Hiroshimashi Japan.
Hiroshima University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prognosis of unresectable gastric cancer remains poor. Multidisciplinary treatment of unresectable gastric cancer is, therefore, thought to be essential for improving patients' outcomes. Here, we report a successful case of multidisciplinary therapy for unresectable gastric cancer. The patient was a 69-year-old woman who was diagnosed with type 2 gastric cancer with remote lymph node metastases and peritoneal dissemination. Although shrinkage of the primary lesion and remote lymph nodes were observed following chemotherapy, we performed distal gastrectomy to deal with continuous bleeding from the primary lesion. Combination therapy with radiation and chemotherapy was effective for multiple metastases in both subclavian lymph nodes and metachronous multiple axillary lymph nodes. Nivolumab combined with radiation therapy also induced regression of remote lymph node metastases, peritoneal dissemination, and adrenal metastasis. Abscopal effects, i.e., shrinkage of the non-irradiated lesions, were also observed. Thus far, the patient has been able to maintain a good quality of life while receiving continued nivolumab therapy. Multidisciplinary therapy including immunotherapy and abscopal effect may improve the quality of life and contribute to long-term survival of patients with unresectable gastric cancer.

Indexed as

Abscopal effectGastric cancerImmunotherapyNivolumabPseudoprogressionRadiation therapy

Identifiers

PMID32904110
PMCPMC7450015
OpenAlexW3045462190

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.