Evidence map›Paper›PMID 32904031›Full record

ArticleCritical care explorations2020

Endothelial Injury and Glycocalyx Degradation in Critically Ill Coronavirus Disease 2019 Patients: Implications for Microvascular Platelet Aggregation.

Douglas D Fraser, Eric K Patterson, Marat Slessarev, Sean E Gill, Claudio Martin, Mark Daley, Michael R Miller, Maitray A Patel, Claudia C Dos Santos, Karen J Bosma and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care explorations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 2 pooled it
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.

  1. Pooled it
  2. The Role of P-Selectin in COVID-19 Coagulopathy: An Updated Review.International journal of molecular sciences · 2021
    Pooled it
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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Douglas D FraserLawson Health Research Institute, London, ON, Canada.
Eric K PattersonLawson Health Research Institute, London, ON, Canada.
Marat SlessarevLawson Health Research Institute, London, ON, Canada.
Sean E GillLawson Health Research Institute, London, ON, Canada.
Claudio MartinLawson Health Research Institute, London, ON, Canada.
Mark DaleyLawson Health Research Institute, London, ON, Canada.
Michael R MillerLawson Health Research Institute, London, ON, Canada.
Maitray A PatelComputer Science, Western University, London, ON, Canada.
Claudia C Dos SantosKeenan Research Center for Biomedical Research, Unity Health Toronto, Toronto, ON, Canada.
Karen J BosmaLawson Health Research Institute, London, ON, Canada.
David B O'GormanLawson Health Research Institute, London, ON, Canada.
Gediminas CepinskasLawson Health Research Institute, London, ON, Canada.
Western University · CALawson Health Research Institute · CAUnity Health Toronto

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesCoronavirus disease 2019 is caused by the novel severe acute respiratory syndrome coronavirus 2 virus. Patients admitted to the ICU suffer from microvascular thrombosis, which may contribute to mortality. Our aim was to profile plasma thrombotic factors and endothelial injury markers in critically ill coronavirus disease 2019 ICU patients to help understand their thrombotic mechanisms.

designDaily blood coagulation and thrombotic factor profiling with immunoassays and in vitro experiments on human pulmonary microvascular endothelial cells.

settingTertiary care ICU and academic laboratory. SUBJECTS: All patients admitted to the ICU suspected of being infected with severe acute respiratory syndrome coronavirus 2, using standardized hospital screening methodologies, had daily blood samples collected until testing was confirmed coronavirus disease 2019 negative on either ICU day 3 or ICU day 7 if the patient was coronavirus disease 2019 positive.

interventionsNone. MEASUREMENT AND MAIN

resultsAge- and sex-matched healthy control subjects and ICU patients that were either coronavirus disease 2019 positive or coronavirus disease 2019 negative were enrolled. Cohorts were well balanced with the exception that coronavirus disease 2019 positive patients were more likely than coronavirus disease 2019 negative patients to suffer bilateral pneumonia. Mortality rate for coronavirus disease 2019 positive ICU patients was 40%. Compared with healthy control subjects, coronavirus disease 2019 positive patients had higher plasma von Willebrand factor (

conclusionsThrombosis profiling identified endothelial activation and glycocalyx degradation in coronavirus disease 2019 positive patients. Our data suggest that medications to protect and/or restore the endothelial glycocalyx, as well as platelet inhibitors, should be considered for further study.

Indexed as

coronavirus disease 2019endothelial injuryglycocalyx degradationplatelet adhesionthrombosis

Identifiers

PMID32904031
PMCPMC7449254
OpenAlexW3080743360

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.